A compound selected from compounds of formula I and salts and solvates thereof: in which: X1, X2 and X3 are independently O or S； Y is (CHR7) n, O or S； wherein n is 1 or 2 and R7 is H, halogen, alkyl, aryl, aralkyl, amino, arylamino, alkylamino, aralkylamino, alkoxy, aryloxy or aralkyloxy； A is a 5-membered heterocycle comprising 1 to 4 heteroatoms optionally substituted with amino, hydroxy, mercapto, halogen, carboxyl, amidino, guanidino, alkyl, alkoxy, aryl, aryloxy, acyl, acyloxy, acylamino, alkoxycarbonylamino, cycloalkyl, alkylthio , alkylsulfinyl, alkylsulfonyl, aminosulfonyl, alkylaminosulfonyl, alkylsulfonylamino or a heterocycle； wherein each substitution with alkyl, alkoxy, aryl, aryloxy, acyl, acyloxy, acylamino, cycloalkyl and heterocycle is optionally substituted with hydroxyl, halogen, mercapto, carboxyl, alkyl, alkoxy, haloalkyl, amino, nitro, cyano, cycloalkyl, aryl or a heterocycle； R1 is H or R1 and R2 together form a 5-8 member ring； R2 is alkyl, cycloalkyl, cycloalkylalkyl, aryl, aralkyl, a heterocycle or heterocyclylalkyl； each optionally substituted with hydroxyl, mercapto, halogen, amino, carboxyl, alkyl, haloalkyl, alkoxy or alkylthio； R3 is H or alkyl； R4 and R4 'are independently H, hydroxyl, amino, alkyl, aryl, aralkyl, cycloalkyl, cycloalkylalkyl, heteroaryl or heteroarylalkyl, wherein each alkyl, aryl, aralkyl, cycloalkyl, cycloalkylalkyl, heteroaryl and heteroarylalkyl is optionally substituted with halogen, hydroxyl, mercapto, carboxyl, alkyl, alkoxy, amino and nitro； R5, and R5 'are each independently H or alkyl； R6, and R6 'are each independently H, alkyl, aryl or aralkyl.Un compuesto seleccionado entre compuestos de fórmula I y sales y solvatos de los mismos: en la que: X1, X2 y X3 son independientemente O o S； Y es (CHR7)n, O o S； en donde n es 1 o 2 y R7 es H, halógeno, alquilo, arilo, aralquilo, amino, arilamino, alquilamino, aralquilamino, alcoxi, ariloxi o aralquiloxi； A es un heterociclo de 5 miembros que comprende de 1 a 4 h
