NOVEL 1H-PYRIMIDIN-2-ONE DERIVATIVES, PREPARATION THEREOF AND PHARMACEUTICAL USE THEREOF AS INHIBITORS OF AKT (PKB) PHOSPHORYLATION农业专利-农业学术服务平台

发明人:: CERTAL, VICTOR,瑟透维克特,瑟透維克特,FILOCHE-ROMME, BRUNO,菲洛契洛米布鲁诺,菲洛契洛米布魯諾,HALLEY, FRANK,哈利法兰克,哈利法蘭克,KARLSSON, KARL ANDREAS,卡尔森卡尔安德瑞斯,卡爾森卡爾安德瑞斯,THOMPSON, FABIENNE,汤普森法比安,湯普森法比安

摘要：: The invention relates to the novel products of formula (I):in which Z represents -O-, -NH, N-cycloalkyl, Nalk or N-phenyl which are optionally substituted n represents 0 to 4 R1 represents H, Hal, hydroxyl,alkyl or alkoxy the alkyl and alkoxy radicals being optionally substituted it being possible for R1 to represent a phenyl radical fused with the phenyl which bears R1 so as to form naphthyl R2 and R3 represent H, Hal or alkyl optionally substituted with one or more halogen atoms R4 represents H these products being in all the isomer forms and the salts, as medicaments, in particular as inhibitors of AKT(PKB) phosphorylation.本發明係關於式(I)之新穎產物:其中Z表示-O-、-NH、N-環烷基、視情況經取代之N烷基或N-苯基;n表示0至4;R1表示H、鹵素、羥基、烷基或烷氧基;該等烷基及烷氧基視情況經取代;R1有可能表示與攜帶R1之苯基稠合從而形成萘基之苯基;R2及R3表示H、鹵素或視情況經一或多個鹵素原子取代之烷基;R4表示H;此等產物可呈所有異構體形式及鹽,其係作為藥劑,特定言之作為AKT(PKB)磷酸化抑制劑。