The present invention relates to a compound or the pharmaceutically acceptable salt thereof with excellent glucokinase activating effect.The compound of the following formula(I):[wherein, A represents an oxygen atom or a sulfur atom; R1represents a C1-6alkyl group, a C1-6alkoxyl group, or a halogeno C1-6alkyl group etc.; A and R1combine with the adjacent carbon atom to form a heterocyclic group which may be independently substituted with 1 to 3 substituents selected from α group ;R2represents a phenyl group which may be independently substituted with 1 to 5 substituents selected from α group or a heterocyclic group which may be independently substituted with 1 to 3 substituents selected from α group; R3represents a hydroxyl group or a C1-6alkoxyl group; substituents α group consists of a halogen atom, a C1-6alkyl group, a C1-6alkyl group substituted with l or 2 hydroxyl groups, a C1-6alkylsulfonyl group, a group of the formula - V-NR5R6(V represents a carbonyl group or a sulfonyl group, each of R5and R6may be the same or different selected from a hydrogen atom and a C1-6alkyl group, or R5and R6combine with the adjacent nitrogen atom to form a 4 to 6 membered heterocyclic saturated ring which may be independently substituted with 1 or 2 groups selected from a C1-6alkyl group and a hydroxyl groups, said 4 to 6 membered heterocyclic saturated ring may further contains one of oxygen atom or nitrogen atom etc.], or the pharmaceutically acceptable salt thereof is provided.本發明為有關具有優異葡萄糖激酶活性化作用之化合物或其藥理容許鹽。如下式(I)化合物或其藥理容許鹽,[式中,A為氧原子、硫原子等;R1為C1-C6烷基、C1-C6烷氧基、C1-C6鹵化烷基等;A和R1為A及R1與結合之碳原子一起形成可有由取代基群α選擇之基獨立1至3個取代之雜環基;R2為可有由取代基群α選擇之基獨立1至5個取代之苯基或可有由取代基群α選擇之基獨立1至3個取代之雜環基;R3為羥基或C1-C6烷氧基;取代基群α為鹵原子、C1-C6烷基、有1或2個羥基取代之C1-C6烷基、C1-C6烷磺醯基、式-V-NR5R6之基(V為羰基或磺醯基,R5、R6可相同或不同為氫原子或C1-C6烷基,或R5及R6與結合之氮原子一起形成可有由C1-C6烷基及羥基選擇之基獨立1或2個取代之4至6員雜飽和環。該4至6員雜飽和環可更含有1個氧原子或氮原子)等]。
