The present invention provides a compound of the following formula(I)(wherein, R1represents an optionally substituted alkyl group etc., either one of R2and R4represents a group of the formula:- Y-R5(wherein, Y represents -O- etc., R5represents a substituted alkyl group(the Substituent may be an optionally substituted cycloalkyl group etc.,), an optionally substituted branch alkyl group etc.,), and the another one of R2and R4represents a hydrogen atom or an optionally substituted alkyl group, R3represents a group of the formula:-C(=O)-Z-R6(wherein, Z represents a group of the formula-NR7- or -NR7-W-, R6represents an optionally substituted cycloalkyl group etc., R7represents a hydrogen atom or an optionally substituted alkyl group, W represents a hydrogen atom, an optionally substituted alkylene group), X represents=N- etc., provided that, the compound wherein R2represents 2- (morpholino)ethoxy group, R3represents N-(1-adamantyl)carbamoyl group, and R1represents benzyl group is excepted) or the pharmaceutically acceptable salt or solvate thereof..提供作為I型11β羥基類固醇脫氫酶抑制劑有用之如下式化合物、其製藥容許鹽或這些之溶劑合物:(式中R1為可有取代之烷基等,R2及R4之任一方為式:-Y-R5(式中Y為-O-等,R5為被取代烷基(取代基為可有取代之環烷基等)、可有取代之分枝狀之烷基等)之基,R2及R4之叧一為氫或可有取代之烷基,R3為式:-C(=O)-Z-R6(式中Z為-NR7-,或NR7-W-之基,R6為可有取代之環烷基等,R7為氫或可有取代之烷基,W為可有取代之伸烷基)之基,X為=N-等,但R2為2-(N-嗎啉基)乙氧基,R3為N-(1-金剛烷基)胺甲醯基,且R1為苄基之情形除外)。
