The present invention is to provide a novel compound (I) shown below, having the anti-virus activity, particularly the HIV integrase inhibitory activity, and a drug containing the same, particularly an anti-HIV drug, as well as a process and an intermediate thereof. (wherein Z 1 is NR 4 ； R 1 is hydrogen or lower alkyl； X is a single bond, a hetero atom group selected from O, S, SO, SO 2 and NH, or lower alkylene or lower alkenylene in which the hetero atom group may intervene； R 2 is optionally substituted aryl； R 3 is hydrogen, a halogen, hydroxy, optionally substituted lower alkyl etc； and R 4 and Z 2 part taken together forms a ring, to form a polycyclic compound, including e.g., a tricyclic or tetracyclic compound.本發明提供一種如下示之新穎化合物(I)，其具有抗病毒活性，特別是HIV接合酶抑制活性，及含其之藥劑，特別是抗-HIV藥劑，與其之製造方法及中間產物。；(I)；(其中；Z1為NR4；R1為氫或低級烷基；X為單鍵、選自O、S、SO、SO2及NH之雜原子、或可插入雜原子基之低級伸烷基或低級伸烯基；R2為選擇性經取代之芳基；R3為氫、鹵素、羥基、選擇性經取代之低級烷基等；且R4與Z2部分一起形成一環、形成一聚環性化合物，包括例如三環狀或四環狀化合物。
