This invention provides a useful nitrogen-containing saturated heterocyclic compound as renin inhibitor. This invention provides a compound or pharmacologically acceptable salts thereof, wherein, the compound is represented by the following formula [1]: Wherein, R1 represents a cycloalkyl or an alkyl, R22 represents an aryl or the like that may be substituted, R represents a lower alkyl, R3, R4, R5 and R6 are the same or different, and represents a hydrogen atom, a carbamoyl that may be substituted, an alkyl or an alkoxycarbonyl that may be substituted.本發明提供一種可用作腎素抑制劑的含氮飽和雜環化合物。一種化合物或其藥理上所允許的鹽，其中，所述化合物係如下式[I]所表，式中，R1表示環烷基或烷基，R22表示可以被取代的芳基等，R表示低級烷基，R3、R4、R5和R6相同或不同，且表示氫原子、可以被取代的胺甲醯基、可以被取代的烷基或烷氧羰基。
