Compounds of the general formula Iwherein each of m and n is independently 0 or 1； R1 and R2, together with the carbon atom to which they are attached, form a heterocyclic ring comprising one or two heteroatoms selected from oxygen, sulfur, -S(O)- and -S(O)2-； R3 is -CHF2, -CF3, -OCHF2, -OCF3, -SCHF2 or -SCF3； X is a bond, -CH2-, or -NH-； A is aryl, cycloalkyl, cycloalkenyl, arylalkyl, heteroaryl, heteroarylalkyl, heterocycloalkyl or heterocycloalkenyl, optionally substituted with one or more, same or different substituents selected from R4； and R4 is hydrogen, amino, thioxo, alkyl, haloalkyl, hydroxyalkyl, alkoxy, haloalkoxy, halogen, oxo, thia, or hydroxy； or pharmaceutically acceptable salts, hydrates or solvates thereof, have been found to exhibit PDE4 inhibiting activity, and may therefore be useful in the treatment of inflammatory diseases and disorders.本發明提供通式I化合物其中m及n各獨立地為0或1；R1及R2與其所連接之碳原子一起形成包含一或兩個選自氧、硫、-S(O)-及-S(O)2-之雜原子的雜環；R3為-CHF2、-CF3、-OCHF2、-OCF3、-SCHF2或-SCF3；X為一鍵、-CH2-或-NH-；A為芳基、環烷基、環烯基、芳基烷基、雜芳基、雜芳基烷基、雜環烷基或雜環烯基，視情況經一或多個選自R4之相同或不同取代基取代；及R4為氫、胺基、硫酮基(thioxo)、烷基、鹵烷基、羥基烷基、烷氧基、鹵烷氧基、鹵素、側氧基(oxo)、硫基(thia)或羥基；或其醫藥學上可接受之鹽、水合物或溶劑合物，已發現其展現PDE4抑制活性，且因此可用於治療發炎疾病及病症。
