LEE, ON,李昂,李昂,HWANG, JENN TSANG,黄振仓,黃振倉,HUNG, CHI Y,洪集英,洪集英
申请号：
TW096117552
公开号：
TWI404531B
申请日:
2007.05.17
申请国别(地区):
TW
年份:
2013
代理人:
摘要：
A huperzine A compound is provided. The huperzine A compound has following formula:, wherein X comprises O or S, Y comprises -O-, -S-, -CH(R4)-, -C(R4)(R5)-, -C(R4)=C(R5)-, -C≡C-, -NH- or -N(R4)-, n is 0, 1 or 2, R3is C(=X)-(Y)n-R1provided that R2is H or R2and R3are combined to form =CH-Ar, wherein R1, R4and R5independently comprise hydrogen, C1-C32alkyl, C2-C32alkenyl, C2-C32alkynyl, C6-C32aryl or C6-C32heteroaryl, in which alkyl, alkenyl, alkynyl, aryl or heteroaryl with one or more substituents comprising halogen, hydroxyl, alkoxy, aryloxyl, amino, alkylamino, arylamino, dialkylamino, diarylamino, imino, alkylimino, arylimino, acylamido, diacylamido, acylimido, cyano, nitro, mercapto, carbamido, carbamoyl, carboxyl, thioureido, thiocyanato, sulfonamido, thio, sulfonyl or sulfinyl, and Ar comprises aryl or heteroaryl.本發明提供一種石杉鹼甲化合物,具有下列化學式:其中X包括氧或硫;Y包括-O-、-S-、-CH(R4)-、-C(R4)(R5)-、-C(R4)=C(R5)-、-C≡C-、-NH-或-N(R4)-;n為0、1或2;R3為C(=X)-(Y)n-R1;以及R2為H或R2與R3鍵結形成=CH-Ar,其中R1、R4與R5獨立地包括氫、C1-C32烷基、C2-C32烯基、C2-C32炔基、C6-C32芳基或C6-C32異芳基,其中烷基、烯基、炔基、芳基或異芳基上具有一或多個取代基,包括鹵素、羥基、烷氧基、芳氧基、胺基、烷胺基、芳胺基、二烷胺基、二芳胺基、亞胺基、烷亞胺基、芳亞胺基、醯胺基、二醯胺基、醯亞胺基、氰基、硝基、硫醇基、脲基、胺甲醯基、羧基、硫脲基、硫氰基、磺醯胺基、硫基、磺酸基或亞磺醯基,以及Ar包括芳基或異芳基。
