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DÉRIVÉ À NOYAU À CINQ CHAÎNONS HÉTÉROCYCLIQUE AROMATIQUE AYANT UNE ACTIVITÉ INHIBITRICE DE TRPV4
专利权人:
塩野義製薬株式会社; LTD.;SHIONOGI & CO., LTD.;SHIONOGI & CO.
发明人:
YUKIMASA, Akira,行正 顕,KOBAYASHI, Naotake,小林 尚武,TAKAYA, Kenji,高谷 健二,HATO, Yoshio,羽藤 啓夫,行正 顕,小林 尚武,高谷 健二,羽藤 啓夫
申请号:
JPJP2013/058722
公开号:
WO2013/146754A1
申请日:
2013.03.26
申请国别(地区):
JP
年份:
2013
代理人:
摘要:
The present invention relates to: a compound represented by formula (I) or a pharmaceutically acceptable salt thereof; and a pharmaceutical composition which contains the compound or the salt.(In formula (I), R1 represents a hydrogen atom, a substituted or unsubstituted alkyl, a substituted or unsubstituted aromatic carbon ring group or the like; X represents -N(R3)-, -O- or -S-; Y represents =C(R4)- or =N-; Z represents -N(R7)-, -O- or -S-; R2 represents a substituted or unsubstituted alkyloxy or a group represented by formula -(CR2aR2b)n-R2c (wherein each R2a independently represents a hydrogen atom, a halogen or the like; each R2b independently represents a hydrogen atom, a halogen or the like; R2a and R2b bonded to the same carbon atom may combine together to form an oxo, a substituted or unsubstituted non-aromatic carbon ring or the like, and two R2a moieties bonded to adjacent carbon atoms and/or two R2b moieties bonded to adjacent carbon atoms may combine together to form a single bond; R2c represents a substituted or unsubstituted aromatic carbon ring group or the like; and n represents an integer of 1-3); each of R3 and R7 independently represents a hydrogen tom, a substituted or unsubstituted alkyl or the like; each of R4 and R5 independently represents a hydrogen atom, a halogen, a substituted or unsubstituted alkyl or the like; and R6 represents a hydrogen atom, a halogen, a substituted or unsubstituted alkyl or the like.)La présente invention concerne : un composé représenté par la formule (I) ou un sel pharmaceutiquement acceptable de celui-ci ; et une composition pharmaceutique qui contient le composé ou le sel. (Dans la formule (I), R1 représente un atome d'hydrogène, un alkyle substitué ou non substitué, un groupe à noyau carboné aromatique substitué ou non substitué ou similaire ; X représente -N(R3)-, -O- ou -S- ; Y représente =C(R4)- ou =N- ; Z représente -N(R7)-, -O- ou -S- ; R2 représente un alkyloxy substitué ou non substitué ou un groupe re
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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