The invention relates (i) to derivatives of pyridino-pyridinones corresponding to formula (I):in whichR1represents a hydrogen atom or a (C1-C4)alkyl group；R2represents a group -(CH2)n'-B where n'=0, 1, 2, 3 or 4 and B represents a (C3-C5)cycloalkyl group, a (C1-C4)alkyl group or a (C1-C4)alkoxy group；Y, Z, VandWrepresent, independently of one another, a -CH- group, a carbon atom, a heteroatom or no atom, it being understood that the ring in which V, W, Y and Z are comprised is a ring comprising 5 or 6 ring members, it being understood that the dotted lines in said ring indicate that the resultant ring is an aromatic ring and it being understood that said ring comprises 0, 1 or 2 heteroatoms；R3andR4represent, independently of one another, groups that may be identical or different, selected from a hydrogen atom and a linear (C1-C4)alkyl group or form, together with the carbon to which they are bound, a (C3-C5)cycloalkyl group；mis an integer equal to 1, 2, 3 or 4；R5represents a hydrogen atom or a (C1-C4)alkyl group；R6represents a group -(CH2)n-Lin which n= 0, 1, 2 or 3, andLis a group selected from aryls with 6 carbon atoms, heteroaryls with 5 or 6 ring members, saturated heterocycles comprising 5, 6 or 7 ring members or form, together with the nitrogen atom to which they are bound, a heterocyclic group, (ii) to their preparation and (iii) to their application in therapeutics as inhibitors of kinase activity of receptors for PDGF ligands and/or of receptors for the FLT3 ligand.本發明係關於(i)對應於式(I)之吡啶并吡啶酮衍生物：其中R1表示氫原子或(C1-C4)烷基；R2表示基團-(CH2)n'-B，其中n'=0、1、2、3或4且B表示(C3-C5)環烷基、(C1-C4)烷基或(C1-C4)烷氧基；Y、Z、V及W彼此獨立地表示基團-CH-、碳原子、雜原子或無原子，應瞭解，該包含V、W、Y及Z之環為包含5個或6個環成員之環，應瞭解，該環中之該等虛線指示該所得環為芳環，且應瞭解該環包含0、1或2個雜原子；R3及R4彼此獨立地表示可相同或不同之基團，R3及R4係選自氫原子及直鏈(C1-C4)烷基，或R3與R4連同其所鍵結之碳一起形成(C3-C5)環烷基；m為等於1、2、3或4之整數；R5表示氫原子或(C1-C4)烷基；R6表示基團-(CH2)n-L，其中n=0、1、2或3，且L為選自以下之基團：具有6個碳原子之芳基、具有
