TAKAHASHI, KEIJI,髙桥啓治,髙橋啓治,WATANABE, TSUNEO,渡辺恒夫,HAYASHI, KEISHI,林圭史,KURIHARA, KAZUNORI,栗原一典,NAKAMURA, TAKANORI,中村典,YAMAMOTO, AKIO,山本明生,NISHIMURA, TAKUYA,西村拓也,KAMIYAMA, TOS
申请号：
TW103104083
公开号：
TW201446766A
申请日:
2014.02.07
申请国别(地区):
TW
年份:
2014
代理人:
摘要：
The present invention addresses the problem of providing a novel tricyclic pyrrolopyridine compound which has a JAK inhibitory activity, and is particularly useful for preventing, treating and/or alleviating autoimmune diseases, inflammatory diseases, or allergic diseases. Provided is a novel tricyclic pyrrolopyridine compound represented by formula (I) (the substituents in the formula are defined in detail in the description, however R1 represents a C1-6 alkyl group, or the like, R2 represents a hydrogen atom, or the like, R3 represents a hydrogen atom, or the like, ring A represents a C3-11 cycloalkane, or the like, L1 represents a C1-6 alkylene group, or the like, and R4 represents NRaRb, or the like), a tautomer of said compound or a pharmaceutically acceptable salt thereof, or a solvate of the compound, the tautomer, or the pharmaceutically acceptable salt.本發明係以提供一種具有JAK阻斷活性，特別對於自身免疫性疾病、發炎性疾病或過敏性疾病之預防、治療及/或改善有用的新穎之3環性吡咯並吡啶化合物為課題。更詳細為提供一種式(I)(式中之各取代基雖在本文中已詳細定義，但R1表示C1-6烷基等，R2表示氫原子等，R3表示氫原子等，環A表示C3-11環烷烴等，L1表示C1-6伸烷基等，R4表示NRaRb等)所示新穎3環性吡咯並吡啶化合物、該化合物之互變異構物或者其醫藥上可被許可之鹽或彼等之溶劑和物。
