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Indole-2-one derivatives disubstituted in 3, its preparation and its application in therapeutic
专利权人:
SANOFI;PULEO, LETIZIA
发明人:
BARONI, MARCO,PULEO, LETIZIA
申请号:
ES08845678
公开号:
ES2384080T3
申请日:
2008.08.14
申请国别(地区):
ES
年份:
2012
代理人:
摘要:
A compound that responds to formula (I): in which: represents a single or double bond, X represents -N <;, -CH <;or Y represents>; N- or>; CH-, it being understood that at least one of X, Y represents N; Ar represents an aryl or heteroaryl group optionally substituted with one or more substituents, identical or different, chosen from halogen atoms, the C1-C6 alkyl, C1-C6 halogenoalkyl, C1-C3 perhalogenoalkyl, C1-C6 alkoxy, C1-C6 alhaloxy groups -C3, aryl; R1 represents a hydrogen atom or a C1-C6 alkyl group, -C (>; = O) -C1-C6 alkyl or -C (>; = O) -aryl; R2, R3 and R4, identical or different, located in any of the available positions of the phenyl core, independently represent a hydrogen atom, a halogen atom, CN, OH, a C1-C6 alkyl group optionally substituted with an atom halogen or an OH; C1-C3 perhaloalkyl, C1-6 alkoxy, C1-C3 perhaloalkoxy, aminocarbonyl, C1-C6-aminocarbonyl alkyl, C1-C6 dialkyl-aminocarbonyl, aryl, aryloxy heteroaryl; the aryl, aryloxy or heteroaryl group may optionally be substituted with a halogen atom, CN, OH or a C1-C6 alkyl, C1-C3 perhaloalkyl or C1-C6 alkoxy group; it being understood that at least one of R2, R3 and R4 is different from H and that the aryl, aryloxy or heteroaryl group may eventually be substituted with a halogen atom, CN, OH or a C1-C6 alkyl group, C1-C3 perhaloalkyl or C1-C6 alkoxy; R5 represents a C1-C6 alkyl or C2-C6 alkenyl group; and n represents 1 or 2; in the form of a base or an acid addition salt; with the exception of 5-chloro-3- (2-chlorophenyl) -1, 3-dihydro-3- [2- (425 methylpiperacin-1-yl) acetamido] indole-2-one.Un compuesto que responde a la fórmula (I) : en la que : representa un enlace sencillo o doble, X representa -N<;, -CH<; o Y representa >;N- o >;CH-, entendiéndose que al menos uno de X, Y representa N ; Ar representa un grupo arilo o heteroarilo sustituido opcionalmente con uno o varios sustituyentes, idénticos o diferentes, elegidos entre los átomos de halógeno, los grupos alquil
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