A compound of the following general formula: ** Formula ** wherein it is bicyclic aromatic heterocycle consisting of pyridine condensed with benzene, one of Y and Z is CR2d, and the other is a chemical bond Ring B is (a) aromatic hydrocarbon monocyclic or bicyclic with 6 to 11 carbons as ring atoms； (b) monocyclic or bicyclic alicyclic hydrocarbon with 3 to 12 carbons as ring atoms； (c) 5 to 11 membered monocyclic or bicyclic aromatic heterocycle containing carbon atoms and 1 to 4 heteroatoms selected from oxygen atoms, sulfur atoms and nitrogen atoms； or (d) 4 to 12 membered monocyclic or bicyclic non-aromatic heterocycle containing carbon atoms and 1 to 4 heteroatoms selected from oxygen atoms, sulfur atoms and nitrogen atoms, Ring C is (a) benzene； or (b) 5 to 6 membered monocyclic aromatic heterocycle containing carbon atoms and 1 to 4 heteroatoms selected from oxygen atoms, sulfur atoms and nitrogen atoms, R1 is (a) hydrogen； (b) C1-C6 alkyl which may be optionally substituted with 1 to 7 groups selected from C3-C7 cycloalkyl, C1-C6 alkoxy, halogen, oxo and hydroxy； (c) C3-C7 cycloalkyl which may be optionally substituted with 1 to 7 groups selected from C1-C6 alkyl, C1-C6 alkoxy and halogen； (d) C1-C6 alkoxy which may be optionally substituted with 1 to 7 groups selected from C3-C7 cycloalkyl, C1-C6 alkoxy, halogen and hydroxy； (e) phenyl which may be optionally substituted with 1 to 3 groups selected from C1-C6 alkyl, C1-C6 haloalkyl, C3-C7 cycloalkyl, C3-C7 halocycloalkyl, C1-C6 alkoxy, C1-C6 halogenoalkoxy and halogen； (f) halogen； or (g) nitrile, R2a, R2b, R2c and R2d are each independently (a) hydrogen； (b) C1-C6 alkyl which may be optionally substituted with 1 to 7 groups selected from C1-C6 alkoxy, C3-C7 cycloalkyl, halogen, oxo and hydroxy； (c) C3-C7 cycloalkyl which may be optionally substituted with 1 to 7 groups selected from C1-C6 alkyl, C1-C6 alkoxy and halogen； (d) C1-C6 alkoxy which may be optionally substituted with 1 to 7 groups selected from
