ALLAN Kristin Elizabet (GB),АЛЛАН Кристин Элизабет (GB),BATT Andzhej Roman (GB),БАТТ Анджей Роман (GB),DEJVI Rebekka Luiz (GB),ДЭЙВИ Ребекка Луиз (GB),EDVARDS Khannakh Dzhoj (GB),ЭДВАРДС Ханнах Джой (,ALLAN Kristin Elizabet,АЛЛАН Кристин Элизабет,BATT Andzhej Roman,БАТТ Анджей Роман,DEJVI Rebekka Luiz,ДЭЙВИ Ребекка Луиз,EDVARDS Khannakh Dzhoj,ЭДВАРДС Ханнах Джой,EVANS Devid Majkl,ЭВАНС Дэвид Майкл
申请号：
RU2015133171
公开号：
RU0002660421C2
申请日:
2014.01.08
申请国别(地区):
RU
年份:
2018
代理人:
摘要：
FIELD: chemistry.SUBSTANCE: invention relates to a compound of formula (I),in which V is selected from C and N so that the aromatic ring containing V is phenyl or pyridine； R2 is absent when V is N； or, when present, R2 is selected from H, alkyl, alkoxy and halogen； R1 and R3 are independently selected from H, alkyl, alkoxy, halogen and CF3； W, X, Y and Z are independently selected from C and N, so that the ring containing W, X, Y and Z is a five-membered aromatic heterocycle； where R5, R6 and R7 are independently absent or independently selected from H, alkyl, aryl and CF3； P represents -C(R10)(R11)NH2； A is selected from aryl and heteroaryl； alkyl is a linear saturated hydrocarbon containing up to 6 carbon atoms (C1-C6), or a branched saturated hydrocarbon containing from 3 to 6 carbon atoms (C3-C6)； alkyl, optionally, may be substituted with -NR12R13； cycloalkyl is a monocyclic saturated hydrocarbon containing from 3 to 7 carbon atoms； alkoxy is a linear O-linked hydrocarbon containing from 1 to 6 carbon atoms (C1-C6), or a branched O-linked hydrocarbon containing from 3 to 6 carbon atoms (C3-C6)； alkoxy, optionally, may be substituted with aryl； aryl is phenyl； aryl, optionally, may be substituted with a substituent selected from alkyl, alkoxy, halogen, CN, -morpholinyl, -piperidinyl, heteroaryl, arylb, -O-arylb, -CH2- arylb, -(CH2)1-3-heteroaryl, -CONR12R13, -(CH2)1-3-NR14R15 and NR12R13； heteroaryl is a 5, 6, 9 or 10-membered mono- or bicyclic aromatic ring containing, where possible, 1 or 2 ring members, independently selected from N, S and O； heteroaryl, optionally, may be substituted with 1 or 2 substituents independently selected from alkyl, alkoxy, morpholinyl, aryl, -(CH2)1-3-aryl, heteroarylb and NR12R13； values of other radicals are given in the patent claim. Invention also relates to a pharmaceutical composition, to the use of a compound, to a method for treating a disease or condition in which plasma kallikrein activity is involved.EFFECT: technical
