GREEN, Luke,GUBA, Wolfgang,JAESCHKE, Georg,JOLIDON, Synese,LINDEMANN, Lothar,RICCI, Antonio,RUEHER, Daniel,STADLER, Heinz,VIEIRA, Eric
申请号：
ES11713288
公开号：
ES2565761T3
申请日:
2011.04.11
申请国别(地区):
ES
年份:
2016
代理人:
摘要：
Ethynyl derivatives of the formula I ** Formula ** in which: U is>； = N- or>； = C (R5) -； V is -CH>； = or -N>； =； W is>； = CH- or>； = N-； with the proviso that only one of U, V or W can be nitrogen, R5 is hydrogen, methyl or halogen； Y is -N (R6) -, -O-, -C (R7 ') (R7) -, -CH2O- or -CH2S (O) 2-； said R6 is hydrogen or C1-4 alkyl and R7 / R7 'independently of one another are hydrogen, hydroxy, C1-4 alkyl or C1-4 alkoxy； R1 is phenyl or heteroaryl, which are optionally substituted by one or two substituents chosen from halogen, C1-4 alkyl and C1-4 alkoxy； R2 / R2 'independently of each other are hydrogen, C1-4 alkyl, hydroxy, C1-4 alkoxy, C3-C6 cycloalkyl, CH2-C1-4 alkoxy or together with the carbon atom to which they are attached can form a C3 cycloalkyl -C6 or a ring containing - CH2OCH2-； m is the number 0, 1 or 2； in the case where m is 1, R3 / R3 'independently of one another are hydrogen, C1-4 alkyl, CH2-C1-4 alkoxy or together with the carbon atom to which they are attached can form a C3-C6 cycloalkyl； or R3 and R2 together with the carbon atom to which they are attached can form a C3-6 cycloalkyl or a ring containing - (CH2) 2OCH2-； n is the number 0 or 1； in the case where n is 1, R4 / R4 'independently of one another are hydrogen, C1-4 alkyl, CH2-C1-4 alkoxy or together with the carbon atom to which they are attached can form a C3-C6 cycloalkyl； R4 and R2 together with the carbon atom to which they are attached can form a C3-6 cycloalkyl； or if n is 0 and Y is -N (R6) -, then R6 and R2 together with the carbon atom and the nitrogen atom to which they are attached can form a C3-6 cycloalkyl； or if n and m are 0, then R2 and R7 together with the carbon atoms to which they are attached can form a C3-6 cycloalkyl； or to a pharmaceutically acceptable acid addition salt, to a racemic mixture or to its corresponding enantiomers and / or optical isomers and / or stereoisomers.Derivados de etinilo de la fórmula I**Fórmula** en la que: U es >；=N- o >；=
