2,3-Dihydrobenzo [1,4] dioxin-2-ylmethyl derivatives as alpha2C antagonists for use in the treatment of diseases of the central and peripheral nervous system
DIN BELLE, DAVID,HOLM, PATRIK,KARLJALAINEN, ARTO,TOLVANEN, ARTO,WOHLFAHRT, GERD,RUMMAKKO, PETTERI.
申请号：
ES08787689
公开号：
ES2502215T3
申请日:
2008.07.18
申请国别(地区):
ES
年份:
2014
代理人:
摘要：
A compound of formula I, ** Formula ** where X is C (R5) (R6) or C (R7) (Ra)； Z is - [C (R4) 2] n- or an individual bond； R1 is, independently in each case, hydroxy, (C1-C6) alkyl, (C1-C6) alkoxy, halogen, halo (C1-C6) alkyl, phenylalkoxy (C1-C6), (C1-C6) alkoxy - (C>； = O) -, CN, NO2, NH2, mono or dialkyl (C1-C6) amino or carboxy； R2 is, independently in each case, H or (C1-C6) alkyl； R3 is, independently in each case, H or (C1-C6) alkyl； R4 is, independently in each case, H, hydroxy, (C1-C6) alkyl, (C1-C6) alkenyl, hydroxy (C1-C6) alkyl, hydroxyalkenyl (C2-C6), (C1-C6) alkoxy (C1-) alkyl C6), (C1-C6) alkenyloxy (C1-C6) alkyl, (C1-C6) alkyl - (C>； = O) -, (C1-C6) alkoxy - (C>； = O) -, (C1-) hydroxyalkoxy C6) (C1-C6) alkyl or (C1-C6) alkoxy (C1-C6) alkoxy (C1-C6) alkyl； or R4 and R4 both attached to the same carbon atom of the ring form, together with the carbon atoms of the ring to which they are attached, a group - (C>； = O)； R5 is H or hydroxy； or R4 and R5 attached to adjacent ring carbon atoms form a bond between the ring carbon atoms to which they are attached； R6 is phenyl unsubstituted or substituted with 1 or 2 substituent (S) R9； R7 is (C1-C6) alkyl, hydroxy (C1-C6) alkyl, (C1-C6) alkoxy (C1-C6) alkyl or (C1-C6) alkoxy - (C>； = O) -； R8 is hydroxy, (C1-C6) alkyl, (C1-C6) alkenyl, (C1-C6) alkoxy, halogen, hydroxyalkyl (C1-C6), haloalkyl (C1-C6), hydroxyalkenyl (C2-C6), hydroxyalkoxy ( C1-C6), haloalkoxy (C1-C6), phenylalkoxy (C1-C6), alkoxy (C1-C6) alkyl (C1-C6), alkenyloxy (C1-C6) alkyl (C1-C6), alkyl (C1-C6) ) - (C>； = O) -, (C1-C6) alkoxy - (C>； = O) -, (C1-C6) alkoxy - (C>； = O) (C1-C6) alkyl, (C1-C6) alkyl ) -S-, (C1-C6) alkyl - (C>； = O) -O-, (C1-C6) alkyl - (C>； = O) -O-(C1-C6) alkyl, hydroxy- (C>； = O) - (C1-C6) alkoxy, hydroxy- (C>； = O) - (C1-C6) alkoxy (C1-C6) alkyl, (C1-C6) alkoxy - (C>； = O) -alkoxy (C1 -C6) (C1-C6) alkyl, (C1-C6) alkyl -S-(C1-C6) alkyl, hydroxyalkyl (C1-C6) -S-(C1-C6) alkyl, (C1-C6) alkoxy ( C1-C6) -S
