Catholic University Industry Academic Cooperation Foundation;Hanmi Science Co., Ltd.;Korea Institute of Science and Technology
发明人:
SON, Jung Beom,JUNG, Seung Hyun,CHOI, Wha Il,JUNG, Young Hee,CHOI, Jae Yul,SONG, Ji Yeon,LEE, Kyu Hang,LEE, Jae Chul,KIM, Eun Young,AHN, Young Gil,KIM, Maeng Sup,CHOI, Hwan Geun,SIM, Tae Bo,HAM, Young
申请号：
ES11737323
公开号：
ES2636262T3
申请日:
2011.01.31
申请国别(地区):
ES
年份:
2017
代理人:
摘要：
A compound selected from the group consisting of a thieno [3,2-d] pyrimidine derivative of formula (I), and a pharmaceutically acceptable salt, hydrate and solvate thereof: wherein, Y is -CH>； = CR1- , -CC-, or -C (>； = O) NR1-； L is -C (>； = O) NR2-, -NR2C (>； = O) -, or -NR2C (>； = O) NR2-； each of R1 and R2 is independently H, C1-6 alkyl, or C3-8 cycloalkyl； R is H, halogen, methyl, or methoxy； E is aryl of up to 14 C atoms, which is unsubstituted or substituted by 1 to 3 substituents selected from the group consisting of halogen, -NO2, -CN, -NH2, -OH, -CF3, C1-6 alkyl, hydroxy-C 1-6 alkyl, C 3-8 cycloalkyl, - (CH 2) n-C 1-6 alkylamino, - (CH 2) n-C 1-6 dialkylamino, - (CH 2) C 1-6 nalkoxy, - (CH 2) n-OS (>； = O) 2-C 1-6 alkyl, - (CH2) nQ, where Q is aryl of up to 14 C atoms and - (CH2) n-heterocycloalkyl C2-13, where n is an integer of 0 to 3, and the aryl and heterocycloalkyl are each independently unsubstituted or substituted with a substituent selected from the group consisting of C1-6 alkyl, hydroxy-C1-6 alkyl, halogen, C1-6 dialkylamino, and C1-6 alkoxy ； or E is phenyl, pyridinyl, quinolinyl, isoquinolinyl, indolyl, isoxazyl, or pyrazolyl, which is unsubstituted or substituted by 1 to 3 substituents selected from the group consisting of halogen, -NO2, -CN, -NH2, -OH, -CF3, C1-6 alkyl, C3-8 cycloalkyl, - (CH2) n-C1-6 alkylamino, - (CH2) n- C1-6 dialkylamino, - (CH2) C1-6 nalkoxy, - (CH2) n- OS (>； = O) 2-C1-6 alkyl, - (CH2) nQ, where Q is aryl of up to 14 C atoms and - (CH2) n-heterocycloalkyl C2-13, where n is an integer number of 0 to 3； and Z is H, -C (>； = O) R 3, C 1-6 alkyl, C 1-6 hydroxyalkyl, C 3-8 cycloalkyl, C 2-7 heterocycloalkyl, aryl of up to 14 C atoms, in which the aryl and heterocycloalkyl are each independently unsubstituted or substituted by C1-6 alkyl, C1-6 alkoxy, C3-8 cycloalkyl, R3-C2-7 heterocycloalkyl or C2-7 heterocycloalkyl, and R is C1-6 alkyl, C3-6 cycloalkyl, or phenyl .Un compuesto seleccionado del grupo que con
