A compound of formula Ia or formula Ib, or a pharmaceutically acceptable salt or ester thereof, wherein R1 is selected from: aryl； heteroaryl； -NHR3； fused aryl-C4-7-heterocycloalkyl； -CONR4R5； -NHCOR6； -C3-7-cycloalkyl； -0-C3-7-cycloalkyl； -NR3R6； and optionally substituted -C1-6 alkyl； wherein said aryl, heteroaryl, fused aryl-C4-7-heterocycloalkyl and C4-7-heterocycloalkyl are each optionally substituted； Q is CN, halogen, or is selected from C1-6-alkyl, C3-7-cycloalkyl, heterocycloalkyl, aryl and heteroaryl, each of which is optionally substituted with one or more substituents A； R2 is selected from hydrogen, aryl, C1-6-alkyl, C2-6-alkenyl, C3-7-cycloalkyl, heteroaryl, C4-7-heterocycloalkyl and halogen, wherein said C1-6-alkyl, Cz-B-alkenyl, aryl, heteroaryl and C4-7-heterocycloalkyl are each optionally substituted； R3 is selected from aryl, heteroaryl, C4-7-heterocycloalkyl, C3-7-cycloalkyl, fused aryl-C-heterocycloalkyl and C1-6-alkyl, each of which is optionally substituted； R4 and R5 are each independently hydrogen, or optionally substituted C3-7-cycloalkyl, aryl, heteroaryl, C1-6-alkyl or C3-6-heterocycloalkyl； or R4 and R5 together with the N to which they are attached form a C3-6-heterocycloalkyl ring； each R6 is independently selected from C1-6-alkyl, C3-7-cycloalkyl, C-heterocycloalkyl, aryl and heteroaryl, each of which is optionally substituted； each R7 is selected from hydrogen, optionally substituted C1-6-alkyl and C3-7-cycloalkyl； each of R8 and R9 is independently hydrogen or optionally substituted C1-6-alkyl； or R8 and R9 together with the N to which they are attached form a C4-6-heterocycloalkyl； each R10 is selected from C3-7-cycloalkyl and optionally substituted C1-6-alkyl； each R11 is independently selected from C1-6-alkyl, C3-7-cycloalkyl, C1-6-alkyl-C3-7-cycloalkyl, C4-7-heterocycloalkyl, aryl and heteroaryl, each of which is optionally substituted； A is selected from halogen, -NR4S02R5, -CN, -OR6, -NR4R5, -NR7R11, hydroxyl, -CF3, -CONR4R5,
