LIN, Hong,LUENGO, Juan I.,RIVERO, Ralph A.,SCHULZ, Mark James,XIE, Ren,ZENG, Jin
申请号：
ES10778369
公开号：
ES2638323T3
申请日:
2010.05.20
申请国别(地区):
ES
年份:
2017
代理人:
摘要：
A compound of formula (I) ** Formula ** wherein R1 is selected from the group consisting of: H, C1-3 alkyl, -S-C1-6 alkyl, -O-C1-6 alkyl, NRaRb, hydroxy, -SH, NH-NH2, C3-6 cycloalkyl, C4-6 heterocycloalkyl, -SO2Ph, -OPh, -SPh, -SO2 (C1-3 alkyl), -O (-C1-3 alkyl (aryl)), and phenyl ； wherein the C3-6 cycloalkyl, C4-6 heterocycloalkyl, -O (-C1-3alkyl (aryl)) and phenyl groups may be substituted with 1 to 5 substituents selected from the group consisting of: hydrogen, halogen, C1- alkyl C6, amino, trifluoromethyl, carboxylic acid, C3-C7 cycloalkyl, heterocycloalkyl, cyano, hydroxy, alkoxy, alkylthio, acetyl, nitro, oxo, and heteroaryl, wherein the heteroaryl is optionally substituted with 1 to 3 groups independently selected from halogen and C1-3 alkyl； R2 is H or C1-3 alkyl； R3 is selected from the group consisting of: C1-6 alkyl, C3-7 cycloalkyl, C4-6 heterocycloalkyl, alkylcarboxy, aryl, - (C1-3 alkyl) (aryl), and heteroaryl； wherein the C3-7 cycloalkyl, C4-6 heterocycloalkyl, aryl, - (C1-3 alkyl) (aryl), and heteroaryl groups may be substituted with 1 to 5 substituents selected from the group consisting of: hydrogen, halogen, C1 alkyl -6, amino, trifluoromethyl, carboxylic acid, C3-C7 cycloalkyl, heterocycloalkyl, cyano, hydroxy, alkoxy, alkylthio, acetyl, nitro, oxo, and heteroaryl, wherein the heteroaryl is optionally substituted with 1 to 3 independently selected groups of halogen C1-3 alkyl； each R4 is independently selected from the group consisting of: C1-3 alkyl, alkoxy, amide, and ester； n is 0-2； m is 0-3； and Ra and Rb are each independently H, or C1-3 alkyl； wherein any alkyl, as used herein, including alkyl chains defined by the term "- (CH2) n", "- (CH2) m", may be linear or branched, saturated or unsaturated, unsubstituted or substituted with 1 to 4 substituents selected from the group consisting of: halogen, trifluoromethyl, alkylcarboxy, amino, amino substituted, cyano, hydroxy, alkoxy, alkylthio, aryloxy, acyloxy, acyl, acylamino, phosphonate, phos
