THOMPSON, LORIN A. III,汤普森 罗林A 三世,湯普森 羅林A 三世,SHI, JIANLIANG,许建良,許建良,WU, YONG-JIN,吴永珍,吳永珍,MARCIN, LAWRENCE R.,玛欣 罗伦斯R,瑪欣 羅倫斯R,RAJAMANI, RAMKUMAR,雷贾曼恩 罗库玛,雷賈曼恩 羅庫瑪,HIGGINS, MENDI A.,希金斯 曼蒂A,希金斯 曼蒂A
申请号：
TW101118387
公开号：
TW201300381A
申请日:
2012.05.23
申请国别(地区):
TW
年份:
2013
代理人:
摘要：
Compounds of formula (I), including pharmaceutically acceptable salts thereof, are set forth herein: wherein X is selected from the group of CH2, O, and NR2 m = 0 or 1 R1 at each instance is selected from the group of halogen, hydroxy, amino, C1-4alkylamino, C1-4dialkylamino, haloC1-4 alkyl, CN, C1-C6 alkyl or cycloalkyl, C1-C6 alkoxy, and C2-C4 alkynyl L is a bond, -NHCO-, -NH-, or L and Z together can be absent Z is a C6-C10- aryl group or a 5-10 membered heterocyclic group which can be further substituted with from 0-3 substituents selected from the group of halogen, haloC1-4 alkoxy, 4-methoxyphenyl, hydroxy, amino, C1-4alkylamino, C1-4dialkylamino, haloC1-4 alkyl, CN, C1-C6 alkyl or cycloalkyl, C1-C6 alkoxy, and C2-C4 alkynyl R2 is selected from the group of hydrogen, benzyl, C1-C6 alkyl or cycloalkyl, C1-C6 alkoxy, acetyl, and methanesulfonyl and R3, R4 and R5 are independently selected from hydrogen or C1-4alkyl.本文闡述式(I)化合物,包括其醫藥學上可接受之鹽:其中X係選自CH2、O及NR2之群;m為0或1;R1在各情況下係選自以下之群:鹵素、羥基、胺基、C1-4烷胺基、C1-4二烷胺基、鹵基C1-4烷基、CN、C1-C6烷基或環烷基、C1-C6烷氧基及C2-C4炔基;L為一鍵、-NHCO-、-NH-,或L連同Z可不存在;Z為C6-C10芳基或5員至10員雜環基,其可進一步經0至3個選自以下之群的取代基取代:鹵素、鹵基C1-4烷氧基、4-甲氧基苯基、羥基、胺基、C1-4烷胺基、C1-4二烷胺基、鹵基C1-4烷基、CN、C1-C6烷基或環烷基、C1-C6烷氧基及C2-C4炔基;R2係選自以下之群:氫、苯甲基、C1-C6烷基或環烷基、C1-C6烷氧基、乙醯基及甲烷磺醯基;且R3、R4及R5獨立地選自氫或C1-4烷基。
