БИЛЛЕН Денис (US),ЧАББ Нэтэн Энтони Логан (US),КЕРТИС Майкл (US),ГРИНВУД Шон ДиДаблЮ (US),МЕНОН Санджай (US),СТАК Тимоти (US),ВЭЙЛЛАНКУРТ Вэлери А. (US)
申请号：
RU2013139630/04
公开号：
RU2013139630A
申请日:
2012.02.23
申请国别(地区):
RU
年份:
2015
代理人:
摘要：
1. A compound of formula (V.1) or formula (V.2) wherein each of Y and Z is independently C or N, each of W, W and W is independently C or N, V is C, N, O or S A together with Y and Z or with V, Y and Z is a 5-7 membered partially saturated or saturated carbocyclic or heterocyclic ring, this heterocyclic ring containing at least 1 to 3 heteroatoms selected from N, O or S, and wherein Ring A is optionally substituted by at least one substituent selected from oxo, = S, = NR, halo, hydroxyl, cyano o, C1-C6 alkyl, C1-C6 haloalkyl, and C1-C4 alkoxy each of R, R6 and R4 independently represents hydrogen, halogen, hydroxyl, cyano, nitro, C1-C6 alkyl, C3-haloalkyl, C1-C6alkoxy, C1-C4 alkyl C3-C6 cycloalkyl, C-Ci haloalkoxy, -C (O) NH, -SF or -S (O) R R3 is halo, cyano, C1-C6 alkyl, C1-C6 haloalkyl, nitro, hydroxyl, -C (O) NR3, C1-C4 alkenyl, C1-C6 alkynyl, -S (O) R or -OR R3 is cyano, C1-C6 alkyl, C3-haloalkyl, C (O) NRR, C-C2-6alkenyl, C1-C6alkynyl, C2-C6 haloalkenyl or C1-C6 haloalkynyl R2 is hydrogen, C1-C6 alkyl, C1-C4 alkyl, C3-C3 cycloalkyl, -C (O) R, -C (S) R, -C (O) NRR, -C (O) C (O) NRR, -S (O) R, -S (O) NRR, -C (NR) R, -C (NR) NRR, C1-10alkylphenyl, C 1 -C 6 alkylheteroaryl or C 1 -C 6 alkylheterocycle, R 1 is hydrogen, C 1 -C 6 alkyl, C 1 -C 6 -alkenyl, C 1 -C 6 alkyl-C-cycloalkyl, C 1 -C 4 alkyl-phenyl, C 1 -C 6 -alkylheteroaryl or C 1 -C 6 alkylheterocycle R 2 is hydrogen, C 1 -C 6 alkyl, yl, or Ci-C6alkoxy R4 is hydrogen, C1-C6 alkyl, hydroxyl, cyano, nitro, -S (O) R3 or C1-C6alkoxy R is C1-C6 alkyl or C3-C6 cycloalkyl optionally substituted with at least one substituent representing Halogen
