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SUBSTITUTED PROLINES / PIPERIDINES AS AN OXEX RECEPTOR ANTAGONISTS
专利权人:
ИОЛАС ТЕРАПЬЮТИКС; ИНК. (US)
发明人:
КАМЕНЕЦКА Теодор (US),ЦЗЯН Жун (US),СУН Синьи (US)
申请号:
RU2014136339
公开号:
RU2014136339A
申请日:
2013.02.06
申请国别(地区):
RU
年份:
2016
代理人:
摘要:
1. The compound of formula (I), where A is aryl or heteroaryl; B is absent or represents aryl, aryloxy, heteroaryl or heteroaryloxy; where each A or B, or both, can be independently unsubstituted or can be, each, independently mono- or are repeatedly substituted by J or R ', or both; D is aryl, aroyl, heteroaryl or heteroaroyl, where D may be unsubstituted or may be mono-or independently repeatedly substituted by J or R', or both; Z is N or O provided that, if Z represents O, R is absent; R independently in each case, halogen, oxo, hydroxy, cyano, (C) alkyl, (C) alkoxy, (C) acyloxy, (C) acylamido, haloalkyl, haloalkoxy, NRR, C (= O) NRR, C (= O) OR, SOR, SONRR, cycloalkyl, heterocyclyl, aryl, aralkyl or heteroaryl; or one or more of the R groups together with the ring to which they are attached form bicyclo [2.2.2], bicyclo [3.3.0] or bicyclo [ 4.3.0] a ring system where any bicyclo-ring system may be cis-fused or trans-fused, where any alkyl, alkoxy, bicyclo-ring, cycloalkyl, heterocyclyl, aryl, aralkyl or heteroaryl can be mono- or independently repeatedly substituted by J or R ', or both; R and R independently in each case are H, (C) alkyl, aralkyl, (C) acyl, or R and R together with the nitrogen atom to which they are bonded form a 4-7 membered ring, optionally containing an additional 1 or 2 NR, O, S, SO or SO, where R is H or (C) alkyl, where any R, R or R may be mono- or independently repeatedly substituted by J or R ', or both; R is H, (C) alkyl or (C) acyl, or R together with D and the nitrogen atom to which they are bonded form a phthalimido group, where f any alkyl, acyl or phthalimido group optionally mono - or independently repeatedly1. Соединение формулы (I),гдеA представляет собой арил или гетероарил;B отсутствует или представляет собой арил, арилокси, гетероарил или гетероарилокси;где каждый A или B, или оба, могут быть независимо незамещены или могут быть, каждый, независимо моно- или многократно замещены J или R', или обоими;D представляет собой ар
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