РЕШ Эстер (DE),ХЕЛИГ Петер (DE),ЛИНДЛИ Дэвид Дж. (US),САНЗГИРИ Йешвант Д. (US),ТУН Пин (US)
申请号：
RU2013124823/04
公开号：
RU2013124823A
申请日:
2011.10.05
申请国别(地区):
RU
年份:
2014
代理人:
摘要：
1. A solid dispersion comprising, in a substantially non-crystalline form, a compound of Formula I where: R is halogen； R and R are H or independently methyl or methoxy； R and R are independently methyl or methoxy if R and R are H, or H if R and R are independently methyl or methoxy； A and A are each independently CH or N； R is C 1-6 alkyl or haloalkyl, C 1-6 alkylsulfonyl or haloalkylsulfonyl, halogen, nitro or cyano； X is —O— or —NH—； Y is - (CH), where n = 0 , 1, 2 or 3； and R is an unsubstituted or substituted 3-7 membered carbocyclic or heterocyclic ring, as defined herein, or is NRR； wherein, if R is NRR, R and R are each independently H or R- (CH) -, and not more than one of R and R denotes H, where each R independently represents a 3-7 membered carbocyclic or heterocyclic ring, optionally substituted with no more than two Z groups, as defined below, and each m independently represents 0 or 1； and, if R denotes a substituted carbocyclic or heterocyclic ring, the substituents on it represent no more than two Z and / or no more than one Z group, and the Z groups are independently selected from (a) C 1-6 alkyl, C 2-6 alkenyl, C 1 2 alkoxy, C 1-6 alkylthio, C 1-6 alkyl, C 1-6 alkylsulfonyl, C 1-6 alkylsulfonylamino, C 1-6 alkylcarbonyl, C 1-6 alkylcarbonylamino and C 1-6 alkylcarboxy, each of which may optionally be substituted with one or more substituents independently selected from halogen, hydroxy, C 1 alkoxy, amino, C 1-6 alkyl, di (C 1-6 alkyl) amines o and cyano, (b) halogen, (e) hydroxy, (f) amino, and (g) oxo groups, and wherein Zoboznachaet (i) another 3-6 membered carbocysteine1. Твердая дисперсия, включающая, в по существу некристаллической форме, соединение Формулы Iгде:Rобозначает галоген；Rи Rобозначают Н или независимо обозначают метил или метокси；Rи Rнезависимо обозначают метил или метокси, если Rи Rобозначают Н, или обозначают Н, если Rи Rнезависимо обозначают метил или метокси；Aи Aобозначают, каждый независимо, CH или N；Rобозначает Cалкил или га
