AICHER, THOMAS DANIEL,ANZEVENO, PETER BIAGIO,LI, RENHUA,KRASUTSKY, ALEXEI PAVLOVYCH,MABRY, THOMAS EDWARD,SAEED, ASHRAF,SNYDER, NANCY JUNE,STEPHENSON, GREGORY ALAN,TIAN, HONGQI,WALLACE, OWEN BRENDAN,WI
申请号：
ES07760191
公开号：
ES2533263T3
申请日:
2007.04.05
申请国别(地区):
ES
年份:
2015
代理人:
摘要：
A compound structurally represented by the formula: ** Formula ** in which: R1 is -H, 5-halogen, -O-CH3 (optionally substituted with one to three halogens) or -CH3 (optionally substituted with one to three halogens )； R2 is -H, -halogen, -O-CH3 (optionally substituted with one to three halogens) or -CH3 (optionally substituted with one to three halogens)； R3 is -H or -halogen； R4 is -OH, -halogen, -cyano, -alkyl (C1-C4) (optionally substituted with one to three halogens), -alkoxy (C1-C6) (optionally substituted with one to three halogens), -SCF3, -C (O) O-C1-C4 alkyl, -O-CH2-C (O) NH2, -cycloalkyl (C3-C8), -O-phenyl-C (O) O-alkyl (C1-C4), - CH2-phenyl, -NHSO2-alkyl (C1-C4), -NHSO2-phenyl (R21) (R21), -alkyl (C1-C4) -C (O) N (R10) (R11), -C (O) N (R10) (R11), ** Formula ** in which the dashed line represents the point of attachment to the R4 position of formula I； in which m is 1, 2 or 3； where n is 0, 1 or 2； and in which when n is 0, then "(CH2) n" is a link； R5 is -H, -halogen, -OH, -CN, -C1-C4 alkyl (optionally substituted with 1 to 3 halogens), -C (O) OH, -C (O) O-C1-C4 alkyl ), -C (O) -C1-C4 alkyl, 5-O-C1-C4 alkyl (optionally substituted with 1 to 3 halogens), -SO2-C1-C4 alkyl, -N (R8) (R8), -phenyl (R21) (R21), -C (O) -NH-cycloalkyl (C3-C6), ** Formula ** in which the dashed line represents the point of attachment to the position indicated by R5 ； in which m is 1, 2 or 3； in which n is 0, 1 or 2, and in which when n is 0, then "(CH2) n" is a link； R6 is -H, -halogen, -CN or-(C1-C4) alkyl (optionally substituted with 1 to 3 halogens), -O-(C1-C4) alkyl (optionally substituted with 1 to 3 halogens) or ** Formula ** R7 is -H, -halogen or-(C1-C4) alkyl (optionally substituted with 1 to 3 halogens)； R8 is, independently at each occurrence, -H, -C1-C6 alkyl (optionally substituted with 1 to 3 halogens), -C (O) -C1-C6 alkyl (optionally substituted with 1 to 3 halogens ), -C (O) -C3-C8-cycloalkyl, - S (O2) -C3-C8 -cycloalkyl or -S (O2) -C1-C3-alkyl (optionally substitu
