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New compounds useful as S100 inhibitors
专利权人:
Active Biotech AB
发明人:
WELLMAR, Ulf,LIBERG, David,EKBLAD, Maria,BAINBRIDGE, Marie,EAST, Stephen,HARGRAVE, Jonathan,PREVOST, Natacha
申请号:
ES15724640
公开号:
ES2620751T3
申请日:
2015.05.22
申请国别(地区):
ES
年份:
2017
代理人:
摘要:
A compound of formula (I) ** Formula ** or a pharmaceutically acceptable salt thereof, where RA, RB and RC are independently selected from H, halogen, cyano, R1O, C1-C6 alkyl optionally substituted with R1O, C3 cycloalkyl- C6 optionally substituted with R1O, R2C (O), R3S, R4S (O) 2, R5OC (O), (R6ON) C (R7), R8R9NC (O), R10R11N, R12S (O) 2NR13, R14S (O) 2NR15C (O), phenyl optionally substituted with one or more R16 moieties, and 5 or 6 membered heterocyclyl optionally substituted with one or more R16 moieties, or one of RA and RC together with RB forms a biradical - (CH2) m- wherein m is an integer from 3 to 5, and the other of RA and RC is selected from H, halogen, cyano, R1O, C1-C6 alkyl optionally substituted with R1O, C3-C6 cycloalkyl optionally substituted with R1O, R2C (O) , R3S, R4S (O) 2, R5OC (O), (R6ON) C (R7), R8R9NC (O), R10R11N, R12S (O) 2NR13, R14S (O) 2NR15C (O), phenyl optionally substituted with one or plus R16 moieties, and 5- or 6-membered heterocyclyl optionally substituted with one or more R16 moieties; each R16 is independently selected from halogen, cyano, nitro, R17O, C1-C6 alkyl optionally substituted with R17O, C3-C6 cycloalkyl optionally substituted with R17O, R18C (O), R19S, R20S (O) 2, R21OC (O), (R22ON) C (R23), R24R25NC (O), R26R27N, R28S (O) 2NR29, and R30S (O) 2NR31C (O); each of R1-R31 is independently selected from H, C1-C6 alkyl, and C3-C6 cycloalkyl; W is a direct link or X1-X2-X3; X1 is C1-C2 alkylene, optionally substituted with C1-C4 alkyl or R32O; X2 is O or is absent; X3 is a direct bond or C1-C2 alkylene, optionally substituted with C1-C4 alkyl or R32O; R32 is selected from H and C1-C4 alkyl; RD is C1-C6 alkyl, or a cyclic moiety selected from phenyl, 4-6 membered heterocyclyl, and C4-C6 cycloalkyl, wherein said cyclic moiety is optionally substituted with one or more R33; each R33 is independently selected from halogen, cyano, C1-C6 alkyl optionally substituted with R34O, C3-C6 cycloalkyl, phenyl, 5- or 6-membered heterocyc
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