MERLA Beatriks (DE),МЕРЛА Беатрикс (DE),KRISTOF Tomas (DE),КРИСТОФ Томас (DE),OBERBERSh Shtefan (DE),ОБЕРБЁРШ Штефан (DE),ShINE Klaus (DE),ШИНЕ Клаус (DE),BARENBERG Gregor (DE),БАРЕНБЕРГ Грегор (DE),F,MERLA BEATRIKS,МЕРЛА Беатрикс,KRISTOF TOMAS,КРИСТОФ Томас,OBERBERSH SHTEFAN,ОБЕРБЁРШ Штефан,SHINE KLAUS,ШИНЕ Клаус,BARENBERG GREGOR,БАРЕНБЕРГ Грегор,FRANK ROBERT,ФРАНК Роберт,KJUNERT SVEN,КЮНЕРТ Свен
申请号：
RU2009118491/04
公开号：
RU0002469037C2
申请日:
2007.10.16
申请国别(地区):
RU
年份:
2012
代理人:
摘要：
FIELD: medicine, pharmaceutics.SUBSTANCE: invention refers to substituted tetrahydropyrrolopyrazines of general formula I, wherein R1, R2 and R3 in each case independently mean hydrogen or groups R1 and R2 or R2 and R3 form a common cycle ； R4 and R5 in each case independently mean H； R6 means branched or unbranched saturated, unsubstituted C1-6-alkyl, or unsubstituted heteroaryl wherein heteroaryl is a 5- or 6-member aromatic residue containing 1 heteroatom specified in a group consisting of N, O and S, or means phenyl wherein phenyl is unsubstituted or single-substituted or double-substituted by 1 or 2 substitutes which in each case are independently specified in a group consisting of F, Cl, Br, I, CF3, C1-6-alkyl, O-C1-6-alkyl, and , or means unsubstituted phenyl attached through C1-3-alkyl chain； R4a, R5a and R6a in each case independently mean H； R7 means (CH2)tC(=O)R8, wherein t is equal to 1, (C=O)(CH2)mNR11R12, wherein m is equal to 1 or 2, C(=O)(CH2)n(C=O)R8, wherein n is equal to 1, 2 or 3, (CH2)sNHC(=O)R8, wherein s is equal to 1 or 2； R8 means NR9R10 or saturated, branched or unbranched, unsubstituted C1-6-alkyl； wherein R9 and R10 in each case independently mean H, saturated, branched or unbranched, unsubstituted C1-6-alkyl, or unsubstituted or saturated C3-8-cycloalkyl, or phenyl, or phenyl attached through C1-3-alkyl wherein the alkyl chain is saturated, branched or unbranched, and wherein phenyl in each case is unsaturated or single or double saturated by 1 or 2 substitutes which independently specified in a group consisting of F, Cl, Br, I, CF3, C1-6-alkyl, O-C1-6-alkyl, pyridyl, and , or unsubstituted heteroaryl attached through C1-3-alkyl wherein heteroaryl is a 5-member aromatic residue 1 heteroatom of which are specified in a group consisting of O and S, wherein the alkyl chain is saturated, branched or unbranched, or heterocyclyl, or heterocyclyl attached through C1-3-alkyl wherein the alkyl chain is saturated, branched or unbranched, and wh
