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Alcohol Derivatives of 1 - phenyl - 2-pyridinyl alquilico as phosphodiesterase inhibitors
专利权人:
CHIESI FARMACEUTICI S.P.A.
发明人:
ELISABETTA, ARMANI,GABRIELE, AMARI,CARMELIDA, CAPALDI,LAURA, CARZANIGA,ORIANA, ESPOSITO
申请号:
TR201907092
公开号:
TR201907092T4
申请日:
2013.12.04
申请国别(地区):
TR
年份:
2019
代理人:
摘要:
Claim 1: A compound characterized in that it is of the general formula (1) wherein: R¹ and R² are different or equal and are independently selected from the group consisting of: H; linear or branched C₁₋₆ alkyl, optionally substituted with one or more substituents selected from C₃₋₇ cycloalkyl and C₅₋₇ cycloalkenyl;a. Halogenated tar c83218d31832626;C₃₋₇ cycloalkyl;C₅₋₇ cycloalkenyl;linear or branched C₂₋₆ alkenyl; and C₂₋₆ linear or branched alkynyl; R³ is H or represents one or more substituents independently selected from the group consisting of CN, NO₂,CF 8323 and halogen atom; Z is a group (ch832244); m = 0 or 1; a is a phenyl ring, which can be optionally replaced by one or more r83088 substitutes;which may be the same or different and are independently selected from the group consisting of: linear or branched C₁₋₆ alkyl optionally substituted with one or more C₃₋₇ cycloalkyl or C₃₋₇ heterocycloalkyl;a. Halogenated tar c83218d31832626;1. C8332121 asphalt;Keywords halogen; nh832222;and OR⁷ where R⁷ is selected from the group consisting of H; C₁₋₁₀ alkyl optionally substituted with a radical selected from C₃₋₇ cycloalkyl,C₃₋₇ heterocycloalkyl,aryl and heteroaryl; C₁₋₁₀ alkyl substituted with an OH group; C₁₋₆ haloalkyl;C₃₋₇ cycloalkyl;C₁₋₄-aminocarbonyl alkyl; C₁₋₄oxycarbonyl alkyl; C₃₋₇ heterocycloalkyl optionally substituted with C₁₋₄ alkyl;and R⁵R⁶N-C₁₋₁₀ alkylene where R⁵ and R⁶ are independently selected from the group consisting of H, linear or branched C₁₋₆ alkyl or, with the nitrogen atom to which they are attached, form a saturated, partially saturated ring or unsaturated, where these rings are optionally substituted with C₁₋₄ alkyl,halogen atoms or R⁷R⁸N-C al alkylene where R⁷ and R⁸ are different or equal and are independently selected from the group consisting of H, linear or branched C₁₋₆ alkyl or, with the nitrogen atom to which they are attached , form a saturated or partially saturated ring; W is selected from the group consisting of: -NR⁹SO₂R¹⁰
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