HUCK, Bayard,JONES, Reinaldo,XIAO, Yufang,NEAGU, Constantin,BANKSTON, Donald,GOUTOPOULOS, Andreas
申请号：
ES11785338
公开号：
ES2594404T3
申请日:
2011.11.11
申请国别(地区):
ES
年份:
2016
代理人:
摘要：
A compound of the formula (II ') ** Formula ** and / or its stereoisomers or tautomers or pharmaceutically acceptable salts of each of the foregoing, including mixtures thereof in all proportions, wherein: R1, R2 are H； R3 ', R3 "are independently H, LA or Hal, R4, R5, R6, R7, R8 are, independently, H, Hal, LA, OH, SH, O (LA), NH2, NH (LA ), N (LA) 2, NO2, CN, OCN, SCN, COOH, COO (LA), CONH2, CONH (LA), WITH (LA) 2, NHCO (LA), NHCONH (LA), NHCONH2, NHSO2 ( LA), CO (LA), SO2NH2, SO2 (LA) or SO2Hal, R5, R6 can form, together with the phenyl group to which they are attached, a 9 or 10-member bicyclic ring system, where 1 or 2 of the non-phenyl carbon atoms may be independently replaced by NH, O or S, where the cycle formed by R5 and R6 may not be substituted or may be mono- or disubstituted with Hal or LA, One of R5 , R6, R7 can be Ar1, O (Ar1), NH (Ar1), CONH (Ar1), NHCO (Ar1), NHCONH (Ar1), NHSO2 (Ar1), CO (Ar1) or SO2 (Ar1), while the other two of R5, R6, R7 are not Ar1, O (Ar1), NH (Ar1), CONH (Ar1), NHCO (Ar1), NHCONH (Ar1), NHSO2 (Ar1), CO (Ar1) or SO2 ( Ar1), Ar1 is a monocyclic aromatic homo- or heterocycle having 0, 1, 2 or 3 atoms of N, O and / or S and 5 or 6 Skeleton atoms, which may not be substituted or, independently of each other, may be mono-, di- or trisubstituted with Hal, LA, OH, SH, O (LA), NH2, NH (LA), N (LA ) 2, NO2, CN, OCN, SCN, COOH, COO (LA), CONH2, CONH (LA), WITH (LA) 2, NHCO (LA), CHO, CO (LA), SO2NH2, SO2 (LA) and / or SO2Hal, LA is unbranched or branched linear alkyl having 1, 2, 3 or 4 C atoms, where 1, 2 or 3 H atoms can be replaced by Hal, and Hal is F, Cl or Br.Un compuesto de la fórmula (II')**Fórmula** y/o sus estereoisómeros o tautómeros o sales farmacéuticamente aceptables de cada uno de los anteriores, incluyendo sus mezclas en todas las proporciones, en donde: R1, R2 son H； R3', R3" son de modo independiente H, LA o Hal, R4, R5, R6, R7, R8 son, de modo independiente, H, Hal, LA, OH, SH, O(LA), NH2, NH(LA), N(LA)2, NO2, CN, OCN
