MERCK PATENT GESELLSCHAFT MIT BESCHRAENKTER HAFTUNG
发明人:
CALDERINI MICHEL,MUSIL DJORDJE,ZENKE FRANK,HEINRICH TIMO
申请号：
ARP110103781
公开号：
AR083402A1
申请日:
2011.10.13
申请国别(地区):
AR
年份:
2013
代理人:
摘要：
The compounds of formula (1) wherein R1 is [c] NAR1 (R4) 2, (CH2) Nhet, (CH2) NCYC, a rest of formula (2) or； R2 is C (R4) [2] nar2, CH [B (OH) 2] ch2het, a rest formula (3), (CH2) Nhet NCYC, (CH2), CH (CCH) phenyl or； R3 is Hal, NH2, Oh, CN, CF3, CHF2 or N3； R4 is H or alkyl with 1, 2, 3 or 4 u00e1tom C i； R2 and R4 are also alquileno together with 2, 3, 4 or 5 c Atoms.Where a group can also be replaced with CH2 NH COA, na, N, N - (CH2) nar3, N - (CH2) nhet2, CH - ch, - O - N - (CH2) nar3, SO2 or and / or can be substituted with a； AR1 is phenyl, naphthyl biphenyl substituted or not or mono -, di -, Tri -, tetra - or pentasustituido with Hal, OA, NH2, Oh, Nha, Na2, NO2, CN, COOH, COOA, CONH2, conha, cona2, nhcoa, nhso2a, COA, Cho, het1, so2nh2 and / or SO2 ar2 is phenyl；Biphenyl substituted naphthyl or not or mono -, di -, Tri -, tetra - or pentasustituido with Hal, OA, NH2, Oh, Nha, Na2, NO2, CN, COOH, COOA, CONH2, conha, cona2, nhcoa, nhso2a, COA, Cho, het1, so2nh2 and / or SO2； AR3 is Not substituted phenyl or mono -, di - or trisustituido with Hal, Oh, oa and / or Het is straight； Cycle or saturated, unsaturated mono - or non substituted bicyclic Aromatic mono - or,Di - or trisustituido with Hal, OA, NH2, Oh, Nha, Na2, NO2, CN, COOH, COOA, (CH2) nconh2, (CH2) nconha, (CH2) ncona2, nhcoa, nhso2a, COA, Cho, het1, so2nh2, SO2 and / or u = 1 to 4 n Atoms and / or or and / or s； het1 is a saturated or unsaturated monocyclic Aromatic heterocycle, not replaced or mono -, di - Or trisustituido with Hal, OA, NH2, Oh, Nha, Na2, NO2, NS,COOH COOA and / or with 1 to 4 and / or n Atoms and / or s； het2 is piridilo, pirimidinilo, furilo, tienilo, imidazolilo, pirrolilo, oxazolilo, oxadiazolilo, isoxazolilo, thiazolyl, triazolilo, tetrazolilo or thiadiazole； is unbranched or branched alkyl with 1 to 10 c Atoms. Where 1 - 7 Atoms H can be replaced with F, CL, BR, I, Cho, COA, cona2, conha COOA, CN, and / or CONH2,And / or where one or two non adjacent groups and
