您的位置: 首页 > 农业专利 > 详情页

New amino-azaheterocyclic carboxamides
专利权人:
MERCK PATENT GMBH
发明人:
SUTTON, AMANDA E.,RICHARDSON, THOMAS E.,HUCK, BAYARD R.,KARRA, SRINIVASA R.,CHEN, XIAOLING,XIAO, YUFANG,GOUTOPOULOS, ANDREAS,LAN, RUOXI,PERREY, DAVID,VANDEVEER, HAROLD,LIU-BUJALSKI, LESLEY,STIEBER, FR
申请号:
ES10705453
公开号:
ES2527940T3
申请日:
2010.02.04
申请国别(地区):
ES
年份:
2015
代理人:
摘要:
A compound of the formula (I) ** Formula ** and pharmaceutically acceptable salts or solvates thereof, wherein: X is N or C-R3, Y is NH, O or absent, R1 is L1-R4-L2-R5 -L3-R6, L1-R4-L2-R5 or L1-R4, R2 is H, A, Hal, OH, OA, SH, CN, NH2, NO2, NHA, NH-L1-Ar, NHCOA, NHCO-L1 -Ar, NHSO2A, NHSO2-L1-Ar, NHCONHA or NHCONH-L1-Ar, L1-Ar, O- L1-Ar, L1-R4, L1 and L3 each, independently of each other, are a single link, branched or unbranched alkylene with 1, 2,3, 4 or 5 atoms, which may be substituted or mono- or di-substituted with Hal, OH, CN, NH2, NH (LA), N (LA) 2, NO2, COOH , N2, ethenyl or ethynyl, and / or mono-substituted with R4, and in which one or two CH2 groups can be replaced by an O or S atom or by a group -NH-, -N (LA) -, -CONH-, -N (LA) COO-, -SO2- or-NHCO, R3 is A, Hal, OH, COOH, SH, NH2, NO2 or CN, R4, R5, R6 each, independently of each other , are Ar, or monocyclic alkyl having 3, 4, 5, 6 or 7 ring atoms, in which one or two CH2 groups can be re placed by an atom of O or S and / or by a group -NH-, -NA-, -CHA-, -CO-, -CH>; = N or -CH>; = CH-, and / or in which the Connection group CH can be replaced by an N atom, and they can be mono- or di-substituted by Hal or LA, L2 is -NHCO-, -NHCOO-, -NHCONH-, -NHCONA-, -NHCOA-, -O-, -S-, -NH-, -NHSO2-, -SO2NH- -CONH-, - CONHCONH-, -NHCONHCO-, or -A-, Ar is a mono- or bicyclic aromatic homo- or heterocycle that has 0, 1, 2, 3 or 4 atoms of N, O and / or S and of 5, 6, 7, 8, 9 or 10 atoms of the skeleton, which can be unsubstituted or, independently of each other, can be mono -, di- or trisubstituted by Hal, A, OH, SH, OA, NH2, NHA, NA2, NO2, CN, OCN, SCN, COOH, COOA, CONH2, CONHA, CONA2, NHCOA, NHCONHA, NHCONH2, NHSO2A, CHO , COA, SO2NH2, SO2A and / or SO2Hal, and in which an atom of an N ring can be substituted by an O atom to form an N-oxide group, and in which in the case of a bicyclic aromatic cycle , one of the two rings can be partially saturated, A is linear or branched or unbranched cyclic alkyl having 1, 2, 3
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

意 见 箱

匿名:登录

个人用户登录

找回密码

第三方账号登录

忘记密码

个人用户注册

必须为有效邮箱
6~16位数字与字母组合
6~16位数字与字母组合
请输入正确的手机号码

信息补充