DONNELLY, Marianne,QIU, Hui,YU, Henry,LIU-BUJALSKI, Lesley,GOUTOPOULOS, Andreas
申请号：
ES12753341
公开号：
ES2568603T3
申请日:
2012.08.22
申请国别(地区):
ES
年份:
2016
代理人:
摘要：
Compound of formula (I) ** Formula ** in which R1 indicates Y, COA, COOA, COO- (CH2) n-Ar, COO- (CH2) n-Cyc； R2, R3 independently indicate Y or SO2Y； R4 indicates Cl, Br, I, COOY, SO2Y, CN, CAr3, (CH2) m-Ar, ** Formula ** or； R5 indicates (CH2) n-Ar, (CH2) n-Cyc, (CH2) n-Het, (CH2) nO-Ar, (CH2) n-CY (OH) -Ar, (CH2) n-CO-Ar or (CH2) n-NYAr； X indicates CH2, CO or CH (OH)； Y indicates H or A； A indicates unbranched or branched alkyl having 1-10 C atoms, in which 1-7 H atoms can be independently replaced by Hal and / or in which a CH2 group can be replaced with a -CH>； group = CH-； Cyc indicates cycloalkyl having 3-7 C atoms, in which 1-4 H atoms can be independently replaced by Hal and / or substituted by Ar； Ar indicates an unsaturated or aromatic mono or bicyclic carbocycle having 3-12 C atoms, which can be substituted with at least one substituent selected from the group of Hal, A, (CY2) n-OY, (CY2) n-NYY, COOY , CONYY, NHCOY, SO2Y, CN and phenoxy； Het indicates a mono, bi or tricyclic unsaturated or aromatic heterocycle having 1-12 C atoms and 1-4 N atoms, which can be substituted with at least one substituent selected from the group of Hal, A, (CY2) n-OY , (CY2) n-NYY, COOY, CONYY, NHCOY, SO2Y, SO2Ar, CN and thiophenyl； Hal indicates F, Cl, Br or I； m indicates 1, 2 or 3； and n indicates 0, 1, 2, 3, 4, 5 or 6； and / or physiologically acceptable salt thereof.Compuesto de fórmula (I)**Fórmula** en la que R1 indica Y, COA, COOA, COO-(CH2)n-Ar, COO-(CH2)n-Cyc； R2, R3 indican independientemente entre sí Y o SO2Y； R4 indica Cl, Br, I, COOY, SO2Y, CN, CAr3, (CH2)m-Ar,**Fórmula** o ； R5 indica (CH2)n-Ar, (CH2)n-Cyc, (CH2)n-Het, (CH2)n-O-Ar, (CH2)n-CY(OH)-Ar, (CH2)n-CO-Ar o (CH2)n-NYAr； X indica CH2, CO o CH(OH)； Y indica H o A； A indica alquilo no ramificado o ramificado que tiene 1-10 átomos de C, en el que 1-7 átomos de H pueden reemplazarse independientemente entre sí por Hal y/o en el que un grupo CH2 puede reemplazarse con un grupo -CH>；=CH-； Cyc indica cicloal
