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HYDROPYRROLOPYRROLE DERIVATIVES FOR USE AS FATTY ACID SYNTHASE INHIBITORS
专利权人:
MERCK PATENT GMBH
发明人:
STAEHLE, WOLFGANG,TSAKLAKIDIS, CHRISTOS,LEUTHNER, BRIGITTA,WIENKE, DIRK,CZAUDERNA, FRANK,WEGENER, ANSGAR
申请号:
SG11201502014X
公开号:
SG11201502014XA
申请日:
2013.08.30
申请国别(地区):
SG
年份:
2015
代理人:
摘要:
Claim 1: compounds of the formula (1) where denotes r\u00b9 or CYC R\u00b2 denotes h, F, CL, BR, Oh, CN, no\u2082, OA, SA, so\u2082me, coa or cona\u2082 R denotes ar or het x\u00b9, X, X, x\u2074 denote each, independently or together, CH N denotes c\u2081\u208b\u2081\u2080 unbranched alkyl R Amificado,Where two adjacent carbon Atoms can form a double bond and \/ or one or two groups ch\u2082 ch and \/ or non adjacent Atoms can be replaced by N, s and o and \/ or where 1 - 7 h Atoms can be replaced by r\u2074 CYC denotes c\u2083\u208b\u2087 cycloalkyl, not replaced Or is monosustituido with Oh, Hal or denotes c\u2081\u208b\u2086 unbranched or branched alkyl,Where 1 - 5 h Atoms can be replaced by F r\u2074 denotes F, CL, BR, Oh, CN, no\u2082, OA, SA, so\u2082me, coa or cona\u2082 ar is phenyl, substituted or not is mono -, di -, Tri -, tetra - or pentasustituido Hal, \u2082 (r\u00b3) [c] \u209aor\u00b3 [c] (r\u00b3) \u2082 \u209an (r\u00b3) \u2082, no\u2082, NS, [c] (r\u00b3) \u2082 \u209acoor\u00b3 [c] (r\u00b3) \u2082 \u209an (\u2082 r\u00b3), N (r\u00b3) \u2082coa, nr\u00b3so\u2082a [c] (r\u00b3) \u2082 \u209aso\u2082n (\u2082 r\u00b3), S (OR) \u2099a or [c] (r\u00b3) \u2082 \u2098n (r\u00b3) \u2082, nhcooa,Nhcon (r\u00b3) \u2082 and \/ or COA r\u00b3 denotes H or alkyl c\u2081\u208b\u2086 unbranched or branched het denotes a mono - or bicyclic heterocycle Aromatic unsaturated or saturated, which has 1 to 4 Atoms of N, o and \/ or s, which can not be replaced or which can be mono -, di -, tri -, tetra - or pentasustituido with h The,, (r\u00b3) \u2082 [c] \u2099or\u00b3 [c] (r\u00b3) \u2082 \u2099n (r\u00b3) \u2082, sr\u00b3, no\u2082, CN, coor\u00b3, (r\u00b3) \u2082, nr\u00b3coa, nr\u00b3so\u2082a, so\u2082n (\u2082 r\u00b3), S (OR) \u2098a,Or [(C r\u00b3) \u2082] \u2099n (r\u00b3) \u2082, nhcooa, nhcon (r\u00b3) \u2082, Cho, COA, = = = NH, S, na and \/ OR = o (carbonyl Oxygen) Hal denotes F, CL, Br or I N1, N2, N3, N4 denote each one, independent of each other,
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