QUATTROPANI, Anna,BAKER-GLENN, Charles,BLACKABY, Wesley,KNIGHT, Chris
申请号：
ES10724789
公开号：
ES2638398T3
申请日:
2010.06.07
申请国别(地区):
ES
年份:
2017
代理人:
摘要：
Compound of formula (I): ** Formula ** where R1 is selected from the following groups: ** Formula ** R2 is selected from the following groups: ** Formula ** R3 indicates Ar2, Het1, Cic or A； A is a branched or linear alkyl having 2 to 12 C atoms, where one or more, preferably 1 to 7 H atoms are substituted by Hal, OR4, CN, CO2R4, CF3, cycloalkyl having 3 to 7 atoms carbon ring, Ar2 or N (R4) 2 and where one or more, preferably 1 to 7 non-adjacent CH2 groups may be substituted by O, NR4, -CO-, NR4CO2-, -CO2-, -NR4CONR4-, CH>； = CH-, -C≡C-, or indicates cycloalkyl or cycloalkylalkylene having 3-7 ring C atoms, or indicates Het1； Z is a branched or linear alkyl having 2 to 12 C atoms, where one or more, preferably 1 to 7 H atoms are substituted by Hal, OR4, CN, CO2R4, CF3, cycloalkyl having 3 to 7 atoms carbon ring, Ar2, N (R4) 2 and / or where one or more, preferably 1 to 7 CH2 groups are substituted by O, NR4, S, -CO-, NR4CO2-, -NR4CONR4-, -CH>； = CH-, -C≡C-, or indicates cycloalkyl or cycloalkylalkylene having 3-7 ring C atoms； Hal is F, CI, Br or I； Ar2 indicates an unsaturated or aromatic, monocyclic or bicyclic carbocyclic ring having from 6 to 14 carbon atoms that may not be substituted or be mono-substituted, disubstituted or trisubstituted by substituents selected from Z, F, Br, I, -OR4, - ( CH2) OR4, - (CH2) N (R4) 2, perfluoroalkoxy, -SO2R4, -CN, -NO2, -N (R4) 2, -CO (NR4) 2, (NR4) COR4, -CO2R4, -COR4, -SO2N (R4) 2, -SO2-(C1-C6) alkyl, NR4SO2-(C1-C6) alkyl, - (CH2) nHet1, -OHet1, or Ar2 indicates an unsaturated or aromatic, monocyclic or bicyclic carbocyclic ring having from 6 to 14 carbon atoms that may be monosubstituted, disubstituted or trisubstituted by CF3, Het1 indicates a saturated, unsaturated or monocyclic heterocyclic ring or a bicyclic saturated or unsaturated heterocyclic ring having 1 to 4 atoms of N and / or O which may not be substituted or monosubstituted, substituted or trisubstituted by substituents selected from A, Hal, -OR4, - (CH2)
