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Diaryloxyadiazole compounds
专利权人:
MERCK SERONO S.A.
发明人:
MONTAGNE, CYRIL,QUATTROPANI, ANNA,SAUER, WOLFGANG,BOMBRUN, AGNÈS
申请号:
ES08804975
公开号:
ES2547877T3
申请日:
2008.10.01
申请国别(地区):
ES
年份:
2015
代理人:
摘要:
A compound according to formula (I) ** Formula ** where R1 and R2 indicate H, W indicates CH or N, Ra is Het, Rb is H, A, Hal, CF3, OCF3, OR3, CN, NO2, (CH2 ) nN (R3) 2, OA, (CH2) nSO2N (R3) 2, (CH2) nNR3SO2A, (CH2) nN (SO2A) 2, NR3CON (R3) 2, NR3COA or (CH2) nSO2R3, Rc is methyl, ethyl or CF3, A is linear or branched alkyl with 1 to 12 C atoms, where one or more atoms, preferably all H atoms, can be substituted by Hal, especially F, or 1 to 7 H atoms can be substituted by OR3, CN or N (R3) 2 and where one or more, preferably 1 to 7 non-adjacent CH2 groups, may be substituted by O, NR3 or S and / or by groups -CH>; = CH- or -C≡C- , or indicates cycloalkyl or cycloalkylalkylene with 3-7 ring C atoms, Hal is F, CI, Br or I, Het indicates one of the following groups: ** Formula ** X1, X2 independently indicate each other F, OCH3, CH3, CF3, OCF3, OH, NO2, CN and / or phenyl, R3 is H or A and n is 0, 1, 2, 3, 4, 5, 6, 7 or 8, and derivatives, solvates, tautomers, salts and stereo pharmaceutically acceptable isomers thereof, including mixtures thereof in all proportions, with the proviso that the compound is not 4- [4- [3- (2-methoxyphenyl) -1,2,4-oxadiazol-5il] -2 -nitrophenyl. ** Formula **Un compuesto según la fórmula (I)**Fórmula** donde R1 y R2 indican H, W indica CH o N, Ra es Het, Rb es H, A, Hal, CF3, OCF3, OR3, CN, NO2, (CH2)nN(R3)2, OA, (CH2)nSO2N(R3)2, (CH2)nNR3SO2A, (CH2)nN(SO2A)2, NR3CON(R3)2, NR3COA o (CH2)nSO2R3, Rc es metilo, etilo o CF3, A es alquilo lineal o ramificado con 1 a 12 átomos de C, donde uno o más átomos, preferiblemente todos los átomos de H, pueden estar sustituidos por Hal, especialmente F, o 1 a 7 átomos de H pueden estar sustituidos por OR3, CN o N(R3)2 y donde uno o más, preferiblemente 1 a 7 grupos CH2 no adyacentes, pueden estar sustituidos por O, NR3 o S y/o por grupos -CH>;=CH- o -C≡C-, o indica cicloalquilo o cicloalquilalquileno con 3-7 átomos de C del anillo, Hal es F, CI, Br o I, Het indica uno de los siguientes grupos:
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