6-Amino-pyrimidine-4-carboxamide derivatives and related compounds that bind to the sphingosine 1-phosphate (s1p) receptor for the treatment of multiple sclerosis
Compounds according to formula (I): ** Formula ** where X is NRaRb, Ra is H or A, Rb is A, A is linear or branched alkyl with 1 to 12 C atoms, where one or more atoms of H may be substituted by Hal, OR3, COOR3, CN or N (R3) 2 and where one or more non-adjacent CH2 groups may be substituted by O, NR3, S or SO2 and / or by groups -CH>； = CH-, or indicates cycloalkyl or cycloalkylalkylene with 3-7 C ring atoms. H is F, CI, Br or I, W is C>； = O, Q is NR3, R is Ar or Het, Ar indicates a saturated, unsaturated carbocyclic ring or monocyclic or bicyclic aromatic with 6 to 14 carbon atoms that may not be substituted or be mono-substituted, disubstituted or trisubstituted with Hal, A, OR3, - [C (R3) 2] n-OR3, N (R3) 2, - [C (R3) 2] nN (R3) 2, NO2, CN, COOR3, CF3, OCF3, CON (R3) 2, NR3COA, NR3CON (R3) 2, - [C (R3) 2] n-Het, - [C (R3) 2] n-Ar, - [C (R3) 2] n-cycloalkyl, - [C (R3) 2] n-CON (R3) 2, - [C (R3) 2] n-COOR3, - [C (R3) 2] n-NR3- [C (R3) 2] n-CO2R3, - [C (R3) 2] n-NR3- [C (R3) 2] n-OR3, -SO2- [C (R3) 2] n-CO2R3, -SO2-N (R3) 2- [C (R3) 2] n-CO2R3, - [C (R3) 2] n-SO2- [C (R3) 2] n-CO2R3, -SO2- [C (R3) 2] n-OR3, -SO2-N (R3) 2- [C (R3) 2] n-OR3, - [C (R3) 2] n-SO2- [C (R3) 2] n-OR3, NR3CON (R3) 2, NR3SO2A , COR3, SO2N (R3) 2, SO2N (R3) A, SOA, SONR3A or SO2A and / or O [C (R3) 2] n-COOR3, Het indicates a saturated, unsaturated or aromatic monocyclic or bicyclic heterocyclic ring with 1 a 4 atoms of N, O and / or S that may not be substituted or be monosubstituted, substituted or trisubstituted with Hal, A, OR3, - [C (R3) 2] n-OR3, N (R3) 2, - [C (R3) 2] nN (R3) 2, NO2, CN, COOR3, CF3, OCF3, CON (R3) 2, NR3COA, NR3CON (R3) 2, - [C (R3) 2] n-Het, - [C (R3) 2] n-Ar, - [C (R3) 2] n-cycloalkyl, - [C (R3) 2] n-CON (R3) 2, - [C (R3) 2] n-COOR3, - [C (R3) 2] n-NR3- [C (R3) 2] n-CO2R3, - [C (R3) 2] n-NR3- [C (R3) 2] n-OR3, -SO2- [C (R3) 2] n-CO2R3, -SO2-N (R3) 2- [C (R3) 2] n-CO2R3, - [C (R3) 2] n-SO2- [C (R3) 2] n- CO2R3, -SO2- [C (R3) 2] n-OR3, -SO2-N (R3) 2- [C (R3) 2] n-OR
