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Oxadiazole Pyridine Derivatives
专利权人:
MERCK SERONO S.A.
发明人:
QUATTROPANI, ANNA,GERBER, PATRICK,DORBAIS, JEROME
申请号:
ES10705889
公开号:
ES2517265T3
申请日:
2010.03.02
申请国别(地区):
ES
年份:
2014
代理人:
摘要:
A compound of formula (I): ** Formula ** Z where R1 indicates -CO2R3, -CON (H) 2-p (A) p, -N (H) (CH2) nCO2R3, -N (R 3) ( CH2) nCO2R3, -NH-CO-A, Hal, -CF3, -OCF3, -OH, - OA, -CN, or -NO2, - (CH2) nHet, - (CH2) sN (H) 2-p ( A) p, -CH (CH3) (CH2) nN (H) 2-p (A) p, -CH (R3) (CH2) nN (H) 2-p (A) p, - (CH2) sN ( R3) (CH2) nCO2R3, - (CH2) sNH-CO-A, - (CH2) nN (R3) 2, -CH (CH3) (CH2) nN (R3) CH (CH3) (CH2) nCO2R3, - CH (R3) (CH2) nN (R3) CH (R3) (CH2) nCO2R3, or when in the target position or with respect to the oxadiazole ring, R1 also indicates -N (H) 2-p (A) or A, R2 is H, Hal, -CN, -NO2, -OH, OA, -CO2R3, -CON (H) 2-p (A) p, -N (H) (CH2) nCO2R3, -NH-CO-A, -CF3, -OCF3, or when in the meta or para position with respect to the oxadiazole ring, R2 also indicates -N (H) 2-p (A) or A, Ra is selected from -CH2-OR3, - ( CH2) sO (CH2) sOMe or CH (CH3) OCH3, Rb is selected from the following groups: -CH3, -CH2-CH3, -CH2-CH (CH3) 2, -CF3, -CH2-CF3, - CH2OCH3, -CH2OCH2CH3, F, Cl, -CH2F, -CF2CH3, -OCF2CH3, -CH2OCF3, -CH2-N (CH3) 2, -CH2-N (CH3) -CH2CH3, -CH (CH3) OCH3, W, Y are independently of each other CH or N, Z indicates Ar or Het, A is a linear or branched alkyl with 1 to 12 C atoms, where one or more H atoms can be substituted by Hal, OR3, CN, CO2R3 or N (R3) 2 and where one or more non-adjacent CH2 groups may be substituted by O, NR3 or S and / or by groups -CH>; = CH- or -C≡C-, or indicates cycloalkyl or cycloalkylalkylene with a ring of 3-7 carbon atoms. Ar indicates a monocyclic or bicyclic, carbocyclic aromatic ring of 6 to 14 carbon atoms, which is unsubstituted or is mono-substituted, disubstituted or trisubstituted by Hal, -CF3, -OCF3, -NO2, -CN, perfluoroalkyl, A, OA, -OH, -NH2, -COH, -COOR3, -CONH2, -CON (H) 2-qAq, -NR3 (CH2) nCOA, -NR3 (CH2) nCOOA, -NR3 (CH2) nCOR3, -N (H) 2-qAq, -NHSO2A, -NHSO2-N (H) 2-m (A) m, -N (H) 1-qAqCOA, -N (H) 1-qAqSO2-N (H) 2-m (A) m, -N (H) 1-qAqCON (H) 2- m (A) m, -COOA, -SO2A, -SO2N (H) 2-m (A) m, -SO2Het, - (CH2) nOR3, Het indicates
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