DORSCH, DIETER,SCHADT, OLIVER,BLAUKAT, ANDREE,STIEBER, FRANK
申请号：
ES07786018
公开号：
ES2525120T3
申请日:
2007.07.12
申请国别(地区):
ES
年份:
2014
代理人:
摘要：
Compounds of the formula I ** Formula ** wherein R1 represents Ar or Het, R2 represents a saturated, unsaturated or aromatic five-membered heterocycle with 1 to 4 atoms of N, O and / or S, which may not be substituted or mono- or di- substituted by Hal, A, (CH2) nOR3, N (R3) 2, SR3, NO2, CN, COOR3, CON (R3) 2, NR3COA, NR3SO2A, SO2N (R3) 2, S ( O) mA, Het1, - [C (R3) 2] nN (R3) 2, - [C (R3) 2] nHet1, O [C (R3) 2] nN (R3) 2, O [C (R3) 2] nHet, S [C (R3) 2] nN (R3) 2, S [C (R3) 2] nHet1, -NR3 [C (R3) 2] nN (R3) 2, -NR3 [C (R3) 2] nHet1, -NR3Het1, NHCON (R3) 2, NHCONH [C (R3) 2] nN (R3) 2, NHCONH [C (R3) 2] nHet1, CON (R3) 2, ONR3 [C (R3) 2 ] nN (R3) 2, CONR3 [C (R3) 2] nHet1, COHet110, COA and / or>； = O (carbonyl oxygen), R3 represents H or A, R4, R5, respectively independently of each other , represent H, Hal, A, OR3, CN, COOR3, CON (R3) 2, NR3COA, NR3SO2A, SO2N (R3) 2 or S (O) mA, A represents unbranched or branched alkyl with 1-10 C atoms , where 1-7 atoms of H can be replaced by F, Cl and / or Br, and / or where one or two CH2 groups they can be replaced by O, S, SO, SO2 and / or by groups CH>； = CH, or cyclic alkyl with 3-7 C atoms, Ar represents phenyl, naphthyl or unsubstituted biphenyl or mono-, di-, or tri - replaced by Hal, A, OR3, N (R3) 2, SR320, NO2, CN, COOR3, CON (R3) 2, NR3COA, NR3SO2A, SO2N (R3) 2, S (O) mA, CO-Het1, Het1 , O [C (R3) 2] nN (R3) 2, O [C (R3) 2] nHet1, NHCOOA, NHCON (R3) 2, NHCOO [C (R3) 2] nN (R3) 2, NHCOO [C (R3) 2] n-Het1, NHCONH [C (R3) 2] nN (R3) 2, NHCONH [C (R3) 2] nHet1, OCONH [C (R3) 2] nN (R3) 2, OCONH [C (R3) 2] nHet1 and / or COA, Het represents a saturated, unsaturated or aromatic mononuclear, binuclear or trinuclear heterocycle with 1 to 4 unsubstituted or mono-di- or tri-substituted N, O or S atoms, A, OR3, N (R3) 2, SR3, NO2 CN, COOR3, CON (R3) 2, NR3COA, NR3SO2A, SO2N (R3) 2, S (O) mA, CO-Het1, Het1, O [C (R3 ) 2] nN (R3) 2, O [C (R3) 2] nHet1, NHCOOA, NHCON (R3) 2, NHCOO [C (R3) 2] nN (R3) 2, NHCOO [C (R3) 2] nHet1
