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Pyridazinone derivatives
专利权人:
Merck Patent GmbH
发明人:
Dorsch, Dieter,Stieber, Frank,Schadt, Oliver,Blaukat, Andree
申请号:
ES14001269
公开号:
ES2614283T3
申请日:
2008.04.29
申请国别(地区):
ES
年份:
2017
代理人:
摘要:
Medication containing at least one compound of the formula I ** Formula ** in which R1 is Ar or Het, R2 is an unsaturated, saturated or aromatic heterocycle with 6 members, with 1 to 4 atoms of N, O and / or S, which is substituted once, twice or three times by N>; = CR3N (R3) 2, SR3, NO2, CN, COR3, CON (R3) 2, NR3COA, NR3SO2A, SO2N (R3) 2, S (O ) mA, [C (R3) 2] nN (R3) 2, [C (R3) 2] nHet, O [C (R3) 2] pOR3, O [C (R3) 2] nN (R3) 2, O [C (R3) 2] nC>; = C [C (R3) 2] nN (R3) 2, O [C (R3) 2] nN + O- (R3) 2, O [C (R3) 2] nHet , S [C (R3) 2] nN (R3) 2, S [C (R3) 2] nHet, NR3 [C (R3) 2] nN (R3) 2, NR3 [C (R3) 2] nHet, NHCON (R3) 2, NHCONH [C (R3) 2] nN (R3) 2, NHCONH [C (R3) 2] nHet, [C (R3) 2] nNHCO [C (R3) 2] nN (R310) 2, [C (R3) 2] nNHCO [C (R3) 2] nHet, CON (R3) 2, CONR3 [C (R3) 2] nN (R3) 2, CONR3 [C (R3) 2] nNR3COA, CONR3 [C (R3) 2] nOR3, CONR3 [C (R3) 2] nHet, COHet, COA, CH>; = CH-COR3 and / or CH>; = CH-N (R3) 2, R3 is H or A, R4, R4 'means in each case independently of each other H, Hal, A, OR3, CN, COR3, CON (R3) 2, NR3COA, NR3SO2A, SO2N (R315) 2 or S (O) mA, Ar means phenyl, naphthyl or biphenyl not substituted os once, twice or three times by Hal, A, [C (R3) 2] nOR3, [C (R3) 2] nN (R3) 2, SR3, NO2, CN, COR3, CON (R3) 2, NR3COA, NR3SO2A, SO2N (R3) 2, S (O) mA, CO-het, Het, O [C (R3) 2] nN (R3) 2, O [C (R3) 2] nHet, NHCOA, NHCON (R3) 2, NHCO [C (R3) 2] nN (R3) 2, NHCO [C (R3) 2] nHet, NHCONH [C (R3) 2] nN (R3) 2, NHCONH [C (R3) 2] nHet, OCONH [C (R3) 2] nN (R3) 2, OCONH [C (R3) 2] nHet, CONR3 [C (R3) 2] nN (R3) 2, CONR3 [C (R320) 2] nHet and / or COA, Het means a heterocycle of one, two or three saturated, unsaturated or aromatic nuclei with 1 to 4 atoms of N, O and / or S, which can be unsubstituted or substituted once, twice, three, four or five times by Hal, A, [C (R3) 2] nOR3, [C (R3) 2] nN (R3) 2, SR3, NO2, CN, COR3, CON (R3) 2, NR3COA, NR3SO2A, SO2N (R3) 2 , S (O) mA, CO-het1, [C (R3) 2] nHet1, O [C (R3) 2] nN (R3) 2, O [C (R3) 2] nHet1, NHCOA, NHC
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