A compound of formula (I) ** Formula ** or pharmaceutically acceptable salt, solvate, or solvate thereof, wherein: X is N or CH； Y is N or CR2； E is a branched or unbranched alkyl linker having 1, 2, 3, 4, 5, 6 or 7 C atoms, which may be unsubstituted or mono- or disubstituted with Hal, OH, CN or NH2, in the that a CH3 group may be substituted by Cyc1, Cyc2, CONH2, CF3, and in which one, two or three CH2 groups may be substituted by -O- or -NH-, and in which a CH group may be substituted by -N-； or if Y is CNH2, E can also be -CH (R3) -NH-CO- or -CO-NH-CH (R3) -； R1 is CN, CONH2, Hal, LA, O (LA), Ar, Cyc1 or Cyc2； R2 is H, NH2, Hal or CN； R3 is H or LA, Hal is F, Cl, Br or I； LA is a saturated or partially unsaturated, unbranched or branched linear hydrocarbon chain having 1, 2, 3, 4, 5 or 6 C atoms, in which 1, 2 or 3 H atoms can be substituted by Hal or OH； Ar is a mono- or bicyclic aromatic homo- or heterocycle having 0, 1, 2, 3 or 4 atoms of N, O and / or S and 5, 6, 7, 8, 9, or 10 skeleton atoms, which they may be unsubstituted or, independently of one another, mono- or disubstituted by Hal, LA, OH, SH, O (LA), NH2, NH (LA), N (LA) 2, NO2, CN, OCN, COOH, COO (LA), CONH2, CONH (LA), WITH (LA) 2, NHCO (LA), NHCONH (LA), NHCONH2, CHO and CO (LA), and / or monosubstituted by Cyc2 or OCyc2； Cyc1 is a 3, 4, 5 or 6-membered monocyclic aliphatic homo- or heterocycle having 0-2 heteroatoms, selected from O, S and N, which may be mono- or disubstituted by Hal, LA, NH2, NH (LA ), N (LA) 2, HO (LA) -； Cyc2 is a 5- or 6-membered monocyclic aliphatic homo- or heterocycle having 0-3 heteroatoms, selected from O, S and N, which may be mono- or disubstituted by Hal or LA； and n is 1 or 2.Un compuesto de fórmula (I)**Fórmula** o sal, solvato, o solvato de sal farmacéuticamente aceptable, del mismo, en la que: X es N o CH； Y es N o CR2； E es un enlazante de alquilo ramificado o no ramificado que tiene 1, 2, 3, 4, 5, 6 o 7 átomos de C, que puede estar no sustituido o mono- o disus
