HUTCHINGS, MARTIN CLIVE,ARCHIBALD, SARAH CATHERINE,BROOKINGS, DANIEL CHRISTOPHER,DAVIS, JEREMY MARTIN,JOHNSON, JAMES ANDREW,LANGHAM, BARRY JOHN,NEUSS, JUDI CHARLOTTE
申请号：
ES07705076
公开号：
ES2471970T3
申请日:
2007.01.30
申请国别(地区):
ES
年份:
2014
代理人:
摘要：
A compound of formula (I), or a pharmaceutically acceptable salt, solvate or N-oxide thereof: ** Formula ** wherein R 1 represents hydrogen, halogen or C 1-6 alkyl； R2 represents halogen or C1-6 alkyl； R3 represents -CONRbRc and Rb and Rc, when considered together with the nitrogen atom to which both are attached, represent azetidin-1-yl, pyrrolidin-1-yl, piperidin-1-yl, morpholin-4-yl, thiomorpholin -4-yl, piperazin-1-yl, homopiperidin-1-yl, homomorpholin-4-yl or homo-piperazin-1-yl, and any of these groups may be optionally substituted with one or more substituents selected from alkyl C1-6, C1-6 alkoxy, hydroxy, hydroxy (C1-6) alkyl, amino (C1-6) alkyl, (amino) (hydroxy) (C1-6) alkyl, halogen, oxo, (C2-6) alkyl carbonyl, carboxy, (C2-6) alkoxycarbonyl, dialkyl (C1-6) hydrazinylcarbonyl, amino, (C1-6) amino, dialkyl (C1-6) amino, (C2-6) carbonylamino, aminocarbonylamino, aminocarbonyl, (C1-6) alkylcarbonyl, dialkyl (C1-6) aminocarbonyl, aminosulfonyl, (C1-6) sulfonyl, (C1-6) alkylcarbonylalkyl (C1-6) alkyl, (C1-6) alkyl (C1-6) alkyl - 6), carboxyalkyl (C1-6), alkoxy (C2-6) carbonylalkyl (C1-6), alkoxy (C2-6) carbonylamino and alkoxy (C2-6) carbo nilaminoalkyl (C1-6).Un compuesto de fórmula (I), o una sal farmacéuticamente aceptable, solvato o N-óxido del mismo: **Fórmula** en donde R1 representa hidrógeno, halógeno o alquilo C1-6； R2 representa halógeno o alquilo C1-6； R3 representa -CONRbRc y Rb y Rc, cuando se consideran junto con el átomo de nitrógeno al cual están unidos ambos, representan azetidin- 1-il, pirrolidin-1-il, piperidin-1-il, morfolin-4-il, tiomorfolin-4-il, piperazin-1-il, homopiperidin-1-il, homomorfolin-4-il u homo-piperazin-1-il, y cualquiera de estos grupos puede estar opcionalmente sustituido con uno o más sustituyentes seleccio-nados entre alquilo C1-6 , alcoxi C1-6, hidroxi, hidroxialquilo(C1-6), aminoalquilo(C1-6), (amino)(hidroxi)alquilo(C1-6), halóge-no, oxo, alquil(C2-6)carbonilo, carboxi, alcoxi(C2-6)carbonilo, dialquil(C1-6)hidrazinilc
