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3-amino-imidazo [1,2-A] pyridine derivatives as SGLT inhibitors
专利权人:
MERCK PATENT GMBH
发明人:
MEDERSKI, WERNER,BEIER, NORBERT,CEZANNE, BERTRAM,GERICKE, ROLF,KLEIN, MARKUS,TSAKLAKIDIS, CHRISTOS
申请号:
ES07725570
公开号:
ES2529691T3
申请日:
2007.05.25
申请国别(地区):
ES
年份:
2015
代理人:
摘要:
Compounds of the formula I wherein R, R ', respectively independently of each other, represent A, OA, Hal, NO2 or COOA, R1, R1', respectively independently of each other, represent H, A , F, Cl, NH2, OH, CN or COOA, R1 "represents H or NH2, R2, R2 ', respectively independently of each other, represent H, Hal, A, OH, OA, CN, NO2, NR4R4 ', CH2NR4R4', O (CH2) mNR4R4 ', O (CH2) mOR4, NH (CH2) mNR4R4', O (C>; = O) (CH2) mNR4R4 ', NH (C>; = O) (CH2) mNR4R4' , CH2O (CH2) mNR4R4 ', CH2OR4, (CH2) mCOOR4, OSO2A, OHet, O (CH2) mCONR4R4', O (CH2) mAr, O (CH2) mCH (OH) (CH2) mOH or OSO2NR4R4 ', R2 and R2 'together represent also -CH>; = CH-CH>; = CH-, R2 "represents H, A, Hal, OH or OA, R3, R3', respectively independently of each other, represents A, OA , Hal, NO2 or COOA, R4, R4 ', respectively independently of each other, represent H or A, A represents unbranched or branched alkyl with 1, 2, 3, 4, 5 or 6 C atoms, in where 1-5 H atoms can be r replaced by F, Het represents tetrahydrofuranyl, tetrahydropyranyl, dioxolanyl, pyrrolidinyl, piperidinyl, morpholinyl or piperazinyl, which can also be mono-substituted by>; = O (carbonyl oxygen), Ar represents phenyl, Hal represents F, Cl, Br or I, m represents 1, 2 or 3, n represents 0, 1 or 2, as well as their salts, solvates and stereoisomers that can be used pharmaceutically, including mixtures thereof in any proportion.Compuestos de la fórmula I en donde R, R', respectivamente de forma independiente el uno del otro, representan A, OA, Hal, NO2 o COOA, R1, R1', respectivamente de forma independiente el uno del otro, representan H, A, F, Cl, NH2, OH, CN o COOA, R1" representa H o NH2, R2, R2', respectivamente de forma independiente el uno del otro, representan H, Hal, A, OH, OA, CN, NO2, NR4R4', CH2NR4R4', O(CH2)mNR4R4',O(CH2)mOR4, NH(CH2)mNR4R4', O(C>;=O)(CH2)mNR4R4', NH(C>;=O)(CH2)mNR4R4', CH2O(CH2)mNR4R4', CH2OR4, (CH2)mCOOR4, OSO2A, OHet, O(CH2)mCONR4R4', O(CH2)mAr, O(CH2)mCH(OH)(CH2)mOH o OSO2NR4R4', R2 y R2' repre
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