Carboxamidas azaheterociclicas biciclicas useful for treating hyperproliferative diseases and inflammatory, Pharmaceutical compositions containing them and Process for preparing them
Claim 1: a compound of the formula (1) and its Salts, solvates and pharmaceutically acceptable salts or solvates of prodrugs, where X is n or C - R3 or NH； and it is, or is absent； R1 - R4 is L1 - L2 - l1 - R4 or R5； R2 is, Hal, oh, OA, NH2, sh, CN, NO2, Nha, NH - L1 L1 - nhco nhcoa, AR, AR, nhso2a, Nhso2 - AR nhconha L1, L1, L1 nhconh - AR, - AR - AR -, or L1, L1 - R4； L1 is a simple Link.Methylene substituted methylene or Methyl, methylene and methylene or Methyl Group substituted with Methyl can not be replaced or may be mono - or alkylated with Hal, Oh, CN, NH2, NH (n), (COOH) 2, NO2, or etinilo ethenyl, N3, and / or monosustituido with R4 and where one or two gr UPOS can be replaced by a CH2 o or s Atom or group - NH, - N (with) - - -(n) - Coo -, - or - nhco - SO2 -； R3 is H, a, Hal, Oh, COOH, NH2, sh, NO2 or CN； R4, R5 are each, independently of each other, or cyclical ar may be mono - or alkylated with Hal or； L2 is nhcoo nhco - - - - - - - - nhconh nhcona nhcoa, -, -, - O -, - S -, - NH -, nhso2 so2nh - - - - - - - - with conhconh, Nhconhco, - - - -； ar is a homo - or mono - or bicyclic Aromatic Heterocycles that have 0, 1, 2,3 or 4 Atoms of N, o and S and / or 5, 6, 7, 8, 9 or 10 Atoms in the Skeleton, which can not be replaced or, independent of each other, can be mono -, di - or trisustituido with Hal, Oh, NH2, sh, OA, Nha, Na2, NO2, OCN, CN, SCN, COOH, COOA, CONH2, conha, cona2, nhcoa, nhconha, nhconh2, nhso 2a, Cho, COA, so2nh2, SO2 and / or so2hal,Where a n Atom can be substituted with a ring to form a group or atom of n-oxide, and where, in the case of a cycle in two bicyclic Aromatic Rings may be partially saturated； is a linear or cyclic alkyl unbranched or branched has 1, 2, 3, 4, 5, 6, 7 or 8 c Atoms.Where one or two CH2 groups can be replaced by an atom of o or s and / or a Group - NH -, co -, nhcoo nhconh - - - - - - - (n), with -, - nhco - or - ch = CH - and where 1 - 3 h Atoms can be replaced by Hal and where one or two CH3 groups can be r
