BIAN Khajan (US),БИАН Хайан (US),ShEVAL'E Kristen M. (US),ШЕВАЛЬЕ Кристен М. (US),KONNOLLI Piter Dzh. (US),КОННОЛЛИ Питер Дж. (US),FLORES Kristofer M. (US),ФЛОРЕС Кристофер М. (US),LIN' Shu-chehn' (US,BIAN KHAJAN,БИАН Хайан,SHEVALE KRISTEN M.,ШЕВАЛЬЕ Кристен М.,KONNOLLI PITER DZH.,КОННОЛЛИ Питер Дж.,FLORES KRISTOFER M.,ФЛОРЕС Кристофер М.,LIN SHU-CHEHN,ЛИНЬ Шу-чэнь,LJU LI,ЛЮ Ли,MEJBUS DZHON,МЕЙБУС
申请号：
RU2011147233/04
公开号：
RU0002549547C2
申请日:
2010.04.22
申请国别(地区):
RU
年份:
2015
代理人:
摘要：
FIELD: medicine, pharmaceutics.SUBSTANCE: invention refers to a compound of formula , wherein Y and Z are independently specified in a group of a) or b) so that one of Y or Z is specified in the group a), and another one - in the group b)； the group a) represents i) substituted C6-10aryl； ii) C3-8cycloalkyl； iii) trifluoromethyl or iv) heteroaryl specified in a group consisting of thienyl, furanyl, thiazolyl, isothiazolyl, oxazolyl, pyrrolyl, pyridinyl, isoxazolyl, imidazolyl, furasan-3-yl, benzothienyl, thieno[3,2-b]thiophen-2-yl, pyrazolyl, triazolyl, tetrazolyl and [1,2,3]thiadiazolyl； the group b) represents i) C6-10aryl； ii) heteroaryl specified in a group consisting of thiazolyl, pyridinyl, indolyl, pyrrolyl, benzoxazolyl, benzothiazolyl, benzothienyl, benzofuranyl, imidazo[1,2-a]pyridin-2-yl, furo[2,3-b]pyridinyl, pyrrolo[2,3-b]pyridinyl, pyrrolo[3,2-b]pyridinyl, thieno[2,3-b]pyridinyl, quinolinyl, quinazolinyl, thienyl and benzimidazolyl； iii) benzofused heterocyclyl attached through a carbon atom, and when a heterocyclyl component contains a nitrogen atom, the carbon atom is optionally substituted by one substitute specified in a group consisting of C3-7cycloalkylcarbonyl； C3-7cycloalkylsulphonyl； phenyl； phenylcarbonyl； pyrrolylcarbonyl； phenylsulphonyl； phenyl(C1-4)alkyl； C1-6alkylcarbonyl； C1-6alkylsulphonyl； pyrimidinyl and pyridinyl； C3-7cycloalkylcarbonyl, phenyl, phenylcarbonyl, phenyl(C1-4)alkyl and phenylsulphonyl are optionally substituted by trifluoromethyl, or by one or two fluor-substitutes； iv) phenoxatiynyl； vi) fluoren-9-on-2-yl； vii) 9,9-dimethyl-9H-fluorenyl； viii) 1-chlornaphtho[2,1-b]thiophen-2-yl； ix) xanthen-9-on-3-yl； x) 9-methyl-9H-carbazol-3-yl； xi) 6,7,8,9-tetrahydro-5H-carbazol-3-yl； xiii) 3-methyl-2-phenyl-4-oxochromen-8-yl； or xiv) 1,3-dihydrobenzimidazol-2-on-5-yl optionally substituted by 1-phenyl, 1-(2,2,2-trifluoroethyl), 1-(3,3,3-trifluoropropyl) or 1-(4,4-difluorocyclohexyl)； 1-phenyl is optionally substituted by one or mo
