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New spiroheterocyclic compounds as antagonists of mGlu5
专利权人:
RECORDATI IRELAND LIMITED
发明人:
LEONARDI, AMEDEO,MOTTA, GIANNI,RIVA, CARLO,GUARNERI, LUCIANO,GRAZIANI, DAVIDE,DE TOMA, CARLO,KARAMFILOVA, KATIA DIMITROVA
申请号:
ES11746494
公开号:
ES2492694T3
申请日:
2011.07.08
申请国别(地区):
ES
年份:
2014
代理人:
摘要:
Compound presenting the general formula I in which: X represents an oxygen or sulfur atom; R1 represents a carbon, nitrogen, oxygen or sulfur atom; R1a represents a group CH, CH2, N or NH; R2 represents a covalent bond or a CH or CH2 group; R3 represents an optionally substituted C1-C6 alkyl group, an optionally substituted monocyclic, bicyclic or tricyclic C1-C13 group comprising between 1 and 5 heteroatoms selected from N, O and S, a monocyclic, bicyclic or tricyclic C6-C14 aryl group optionally substituted, an optionally substituted C3-C6 cycloalkyl group or an optionally substituted C3-C6 cycloalkenyl group, when R1 represents a carbon atom: R4 represents a hydrogen atom, a halogen atom, a monocyclic or bicyclic C1-C9 heterocyclic group optionally substituted comprising between 1 and 3 heteroatoms selected from N, O and S, or an optionally substituted monocyclic, bicyclic or tricyclic C6-C14 aryl group; R5 represents a hydrogen or halogen atom, a cyano group, or an optionally substituted hydroxy, mercapto, amino, carbamoyl, C1-C6 alkyl group, or a C1-C6 alkoxy group, or a group of the formula -C (>; = O) - R6 in which R6 represents an optionally substituted C1-C6 alkyl group or C1-C6 alkoxy group, an optionally substituted monocyclic or bicyclic C1-C9 heterocyclic group comprising between 1 and 3 heteroatoms selected from N, O and S, or an optionally substituted monocyclic, bicyclic or tricyclic C6-C14 aryl group; or R4 and R5 together represent an oxo group or an optionally substituted methylene group or a hydroxyimino group; or R4 and R5 together with R1 represent an optionally substituted unsaturated 4- to 6-membered ring comprising between 0 and 3 heteroatoms selected from N, O and S; when R1 represents an oxygen atom: R4 and R5 are missing; when R1 represents a nitrogen atom: one of R4 and R5 is missing, and the other is as defined above; when R1 represents a sulfur atom: each of R4 and R5, independently, is missing or represents an oxo group.Compuesto qu
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