MARSILJE, THOMAS H.,GRAY, NATHANAEL S.,JIANG, TAO,LU, WENSHUO,PAN, SHIFENG
申请号：
ES04752678
公开号：
ES2379169T3
申请日:
2004.05.19
申请国别(地区):
ES
年份:
2012
代理人:
摘要：
Selected compound of formula I: in which: A is chosen from -C (O) OH； X1 and X2 are each independently selected from a C1-6 alkylene or bond； Z is selected from: where the left and right asterisks of Z indicate the junction point between -C (R3) (R4) - and A of formula I, respectively； R6 is chosen from hydrogen and C1-6 alkyl； R1 is selected from C6-10 aryl and C2-9 heteroaryl； wherein any aryl or heteroaryl of R1 is optionally substituted with a radical selected from halogen, C6-10 aryl-C0-4 alkyl, C2-9 heteroaryl-C0-4 alkyl, C3-8 cycloalkyl-C0-4 alkyl, heterocycloalkyl C3-8-C0-4 alkyl or C1-6 alkyl； wherein any aryl, heteroaryl, cycloalkyl or heterocycloalkyl group of R 1 may be optionally substituted with one to five radicals selected from halogen, C 1-6 alkyl, C 1-6 alkoxy, C 1-6 alkyl substituted by halogen and C 1-6 alkoxy halogen substituted； and any alkyl group of R1 may optionally have a methylene replaced with an atom or group selected from -S-, -S (O) -, -S (O) 2-, -NR5- and -O-； wherein R5 is chosen from hydrogen or C1-6 alkyl； R2 is selected from C1-6 alkyl, C1-6 alkoxy, C3-12 cycloalkyl-C0-4 alkyl, halogen, halogen substituted C1-6 alkyl and halogen substituted C1-6 alkoxy； R3 and R4 are both hydrogen. and pharmaceutically acceptable salts, hydrates, solvates, optical isomers and cis / trans isomers thereof.Compuesto seleccionado de fórmula I: en la que: A se elige de -C(O)OH； X1 y X2 se seleccionan cada uno independientemente de un enlace o alquileno C1-6； Z se selecciona de: en las que los asteriscos izquierdo y derecho de Z indican el punto de unión entre -C(R3)(R4)- y A de fórmula I, respectivamente； R6 se elige de hidrógeno y alquilo C1-6； R1 se elige de arilo C6-10 y heteroarilo C2-9； en los que cualquier arilo o heteroarilo de R1 está opcionalmente substituido con un radical elegido de halógeno, aril C6-10-alquilo C0-4, heteroaril C2-9-alquilo C0-4, cicloalquil C3-8-alquilo C0-4, heterocicloalquil C3-8-alquilo C0-4 o alquilo C1-6； en los que cu
