您的位置: 首页 > 农业专利 > 详情页

Immunosuppressive compounds and compositions
专利权人:
Novartis AG
发明人:
PAN, Shifeng,GRAY, Nathanael S.,FAN, Yi,GAO, Wenqi,MI, Yuan
申请号:
ES04752676
公开号:
ES2558761T3
申请日:
2004.05.19
申请国别(地区):
ES
年份:
2016
代理人:
摘要:
A compound of Formula I: ** Formula ** in which: n is 1 or 2; A is - (CH2) 2C (O) OH; X is a bond or is selected from [1,2,4] oxadiazole, -CH2O-, -OCH2-, isoxazoles and [1,3,4] oxadiazole; Y is selected from phenyl and benzooxazolyl; R1 is chosen from C6-10 aryl and C2-9 heteroaryl; wherein any aryl or heteroaryl of R1 is optionally substituted with a radical selected from C6-10 aryl-C0-4 alkyl, C2-9 heteroaryl-C0-4 alkyl, C3-8 cycloalkyl-C0-4 alkyl, C3- heterocycloalkyl 8-C0-4 alkyl and C1-6 alkyl; wherein any aryl, heteroaryl, cycloalkyl or heterocycloalkyl group of R 1 may be optionally substituted with one to five radicals selected from halo, C 1-6 alkyl, C 1-6 alkoxy, C 1-6 alkyl substituted by halo, and C 1- alkoxy 6 substituted with halo; and any alkyl group of R1 may optionally have a methylene substituted by an atom or group selected from -S-, -S (O) -, -S (O) 2-, -NR7- and -O-; wherein R7 is chosen from hydrogen and C1-6 alkyl; and R2, R3, R4 and R5 are hydrogen; and salts, hydrates, solvates, N-oxide derivatives, optical or geometric isomers selected from cis compounds, trans compounds and mixtures thereof, pharmaceutically acceptable.Un compuesto de Fórmula I:**Fórmula** en la que: n es 1 o 2; A es -(CH2)2C(O)OH; X es un enlace o es seleccionado de entre [1,2,4]oxadiazol, -CH2O-, -OCH2-, isoxazoles y [1,3,4]oxadiazol; Y es seleccionado de entre fenilo y benzooxazolilo; R1 es escogido de entre arilo C6-10 y heteroarilo C2-9; en donde todo arilo o heteroarilo de R1 está opcionalmente sustituido con un radical elegido de entre aril C6-10-alquilo C0-4, heteroaril C2-9-alquilo C0-4, cicloalquil C3-8-alquilo C0-4, heterocicloalquil C3-8-alquilo C0-4 y alquilo C1-6; en donde todo grupo arilo, heteroarilo, cicloalquilo o heterocicloalquilo de R1 puede estar opcionalmente sustituido con de uno a cinco radicales escogidos de entre halo, alquilo C1-6, alcoxilo C1-6, alquilo C1-6 sustituido con halo, y alcoxilo C1-6 sustituido con halo; y todo grupo alquilo de R1 pu
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

意 见 箱

匿名:登录

个人用户登录

找回密码

第三方账号登录

忘记密码

个人用户注册

必须为有效邮箱
6~16位数字与字母组合
6~16位数字与字母组合
请输入正确的手机号码

信息补充