ALLEN, JOHN,BRINER, KARIN,COHEN, MICHAEL,GALKA, CHRISTOPHER,HELLMAN, SARAH,MARTINEZ-GRAU, MARIA ANGELES,REINHARD, MATTHEW,RODRIGUEZ, MICHAEL,ROTHHAAR, ROGER,TIDWELL, MICHAEL,VICTOR, FRANTZ,WILLIAMS, A
申请号：
ES05723397
公开号：
ES2466641T3
申请日:
2005.02.18
申请国别(地区):
ES
年份:
2014
代理人:
摘要：
A compound of Formula I: ** Formula ** in which: R1 is hydrogen； each R2, R3 and R4 is independently hydrogen； R5 is hydrogen； R6 is -NR24R25； R7 is halo； R8 is hydrogen； R9 is hydrogen； R24 is Ph2-n-(C1-C3) alkyl, said Ph2-n-(C1-C3) alkyl optionally substituted on the n-alkyl moiety when present with (C1-C3) alkyl, dimethyl or gem-ethane； R25 is hydrogen, (C1-C3) alkyl optionally substituted with 1 to 6 fluoro substituents, or allyl； R26 is hydrogen, (C1-C6) alkyl optionally substituted with 1 to 6 fluoro or cycloalkyl (C3-C7) substituents (C0-C3) alkyl； R27 is hydrogen or (C1-C4) alkyl optionally substituted with 1 to 6 fluoro substituents, or R26 and R27, taken together with the nitrogen atom to which they are attached, form Het1； R28 is (C1-C8) alkyl optionally substituted with 1 to 6 substituents fluoro, cycloalkyl (C3-C8) -alkyl (C0-C3), tetrahydropyran-3-ylalkyl (C0-C3), tetrahydropyran-4-ylalkyl (C0-) C3), tetrahydrofuranylalkyl (C0-C3), Ph1-n-alkyl (C0-C2) or Ar2-n-alkyl (C0-C2), said Ph1-n-alkyl (C0-C2) and Ar2-n-alkyl (C0-C2) optionally substituted on the alkyl moiety when present with (C1-C3) alkyl, dimethyl or gem-ethane； R29 is hydrogen or (C1-C3) alkyl； R30 is hydrogen, (C1-C6) alkyl optionally substituted with 1 to 6 substituents fluoro, cycloalkyl (C3-C7) -alkyl (C0-C3), Ph1-alkyl (C0-C3) or Ar2-alkyl (C0-C3) , R31 is hydrogen or (C1-C6) alkyl optionally substituted with 1 to 6 fluoro substituents, or R30 and R31, taken together with the nitrogen atom to which they are attached, form Het1, said Het1 also being optionally substituted with optionally substituted phenyl additionally with 1 to 3 halo substituents.Un compuesto de Fórmula I:**Fórmula** en la que: R1 es hidrógeno； cada R2, R3 y R4 es independientemente hidrógeno； R5 es hidrógeno； R6 es -NR24R25； R7 es halo； R8 es hidrógeno； R9 es hidrógeno； R24 es Ph2-n-alquilo (C1-C3), dicho Ph2-n-alquilo (C1-C3) opcionalmente sustituido en el resto n-alquilo cuando está presente con alquilo (C1-C3), dime
