XIE, JIN,PROMO, MICHELE ANN,JACOBSEN, ERIC JON,HUANG, HORNG-CHIH,MADDUX, TODD
申请号：
ES10807506
公开号：
ES2461967T3
申请日:
2010.12.06
申请国别(地区):
ES
年份:
2014
代理人:
摘要：
A compound of Formula I: ** Formula ** or a pharmaceutically acceptable salt thereof； wherein: R1 is selected from the group consisting of hydrogen and (C1-C6) alkyl； and when R1 is hydrogen, then R2 is selected from the group consisting of (C5-C6) alkyl, halo (C1-C6) alkyl, (C3-C6) cycloalkyl (C1-C6) alkyl, hydroxy (C5-C6) alkyl , (C1-C6) alkenyl, (C1-C6) haloalkenyl, phenyl, phenyl (C1-C6) alkyl, cycloalkyl (C3-C6), heterocyclyl and heterocyclyl (C1-C6) alkyl； when R1 is (C1-C6) alkyl, then R2 is selected from the group consisting of (C1-C6) alkyl, halo (C1-C6) alkyl, (C3-C6) cycloalkyl (C1-C6) alkyl, hydroxyalkyl ( C1-C6), alkenyl (C1-C6), phenyl, phenylalkyl (C1-C6), cycloalkyl (C3-C6), heterocyclyl and heterocyclylalkyl (C1-C6)； wherein cycloalkyl (C3-C6), wherever present, is optionally substituted with one or more substituents selected from the group consisting of hydroxyalkyl (C1-C6), phenyl, phenylalkyl (C1-C6) and alkoxycarbonylamino (C1 -C6)； and wherein when R1 is hydrogen and R2 is cyclobutyl, then the cyclobutyl is substituted with one or more substituents selected from the group consisting of hydroxyalkyl (C1-C6), phenyl, halophenyl, phenylalkyl (C1-C6) and alkoxycarbonylamino (C1-C6)； wherein phenyl, wherever present, is optionally substituted with one or more substituents independently selected from the group consisting of cyano, halo, hydroxy, (C1-C6) alkyl, haloalkyl (C1-C6), cyanoalkyl (C1 -C6), (C1-C6) alkoxy, aminosulfonyl and alkylaminosulfonyl (C1-C6)； wherein heterocyclyl, wherever present, is optionally substituted with one or more substituents independently selected from the group consisting of halo, (C1-C6) alkyl, (C1-C6) alkoxy, amino and (C1-C6 alkylamino) )； and wherein the (C1-C6) alkyl in phenylalkyl (C1-C6) and heterocyclylalkyl (C1-C6) alkyl is optionally substituted with a more substituent independently selected from the group consisting of halo and hydroxy； and R3 selected from the group consisting of hydrogen and (C1-C6) alkyl.U
