BLANEY, JEFFREY,GIBBONS, PAUL A.,HANAN, EMILY,LYSSIKATOS, JOSEPH P.,MAGNUSON, STEVEN R.,PASTOR, RICHARD,RAWSON, THOMAS E.,ZHOU, AIHE,ZHU, BING-YAN
申请号：
ES09824234
公开号：
ES2545541T3
申请日:
2009.11.02
申请国别(地区):
ES
年份:
2015
代理人:
摘要：
Compound of Formula Ia: ** Formula ** enantiomers, diastereomers or pharmaceutically acceptable salts thereof, wherein: R1 is H； R2 is -OR4, -NR3R4, -NR3NR12R4, -NR3S (O) R4 or -NR3S (O) 2R4； R3 is H or C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, wherein said alkyl, alkenyl and alkynyl are optionally substituted with oxo, F, ORa or NRaRb； R4 is H, C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, - (C0-C5 alkyl) (C1-C9 heterocyclyl), - (C0-C5 alkyl) (C3-C6 cycloalkyl), - (alkyl C0-C5) (C1-C9 heteroaryl), - (C0-C5 alkyl) (C6-C10 aryl), wherein said alkyl, alkenyl and alkynyl are optionally substituted with R8, and said aryl, cycloalkyl, heteroaryl and heterocyclyl are optionally substituted with R9； or R3 and R4 are taken together with the nitrogen to which they are attached to form a C1-C9 heterocyclyl optionally substituted with R13； Z is -NR5R6； R5 is H； R6 is H, C1-C10 alkyl, C2-C10 alkenyl, C2-C10 alkynyl, - (C0-C5 alkyl) (C1-C9 heterocyclyl), - (C0-C5 alkyl) (C3-C8 cycloalkyl), - (alkyl C0-C5) (C1-C9 heteroaryl), - (C0-C5 alkyl) (C6-C9 aryl), wherein said alkyl, alkenyl and alkynyl are optionally substituted with R10, and said aryl, cycloalkyl, heteroaryl and heterocyclyl are optionally substituted with R11； R7 is H； R8 is independently oxo, halo, ORa or NRaRb； R9 is independently oxo, -CN, -CF3, halo, -C (O) C1-C6 alkyl, -C (O) ORa, -C (O) NRaRb, - (C0-C5 alkyl) NRaRb, - (C0 alkyl -C5) ORa, - (C0-C5 alkyl) SRa, -O [C (Ra) 2] 1-3O-, C1-C3 alkyl optionally substituted with oxo or F, - (C0-C5 alkyl) (C3 cycloalkyl) C6) optionally substituted with oxo or F, - (C0-C5 alkyl) C1-C9 heterocyclyl optionally substituted with halo, oxo, C1-C3 alkyl or C (O) C1-C3 alkyl, - (C0-C5 alkyl) C6 aryl optionally substituted with halo or C1-C3 alkyl, -O (C1-C3 alkyl), or - (C0-C5 alkyl) C1-C9 heteroaryl optionally substituted with halo or C1-C3 alkyl； R10 is independently oxo, halo, ORa or NRaRb； R11 is independently oxo, -CN, -CF3, halo, -O [C (Ra) 2] 1-3O-, -C (O) C1-C6 alkyl, -C (O) O
