The present invention relates to novel acylaminocycloalkyl compounds, in particular to the compounds of the formula I as described herein and to their salts and N-oxides. The compounds possess valuable therapeutic properties and are suitable, in particular, for treating diseases that respond to modulation of the dopamine D3 receptor. In formula I, the variables have the following meanings: m is 1 or 2, n is 1 or 2, A is selected from the group consisting of CH2, CH2CH2, CHFCH2 and CF2CH2, R1 is an oxygen containing cyclic radical selected such as C3-C6 cycloalkyl, which car-ries one or two oxygen containing radicals selected from the group consisting of OH, C1-C2-alkoxy, fluorinated C1-C2-alkoxy, and a carbonyl oxygen, , R2 is selected from the group consisting of hydrogen, OH and fluorine, R3a is selected from the group consisting of hydrogen and methyl, R3b is selected from the group consisting of hydrogen and methyl, R4 is branched C4-C6 alkyl or branched fluorinated C4-C6 alkyl, and R5 is inter alia C1-C6 alkyl, fluorinated C1-C3 alkyl, C1-C2-alkoxy-C1-C4-alkyl, fluorinated C1-C2-alkoxy-C1-C4-alkyl, hydroxy-C1-C4-alkyl, fluorinated hydroxy-C1-C4-alkyl, oxetanyl, fluorinated oxetanyl, oxolanyl, fluorinated oxolanyl, C3-C5 cycloalkyl, fluorinated C3-C5 cycloalkyl, etc.本發明係關於新穎醯胺基環烷基化合物，尤其關於如本文所描述之式I化合物及其鹽及N-氧化物。該等化合物具有有價值之治療性質，且尤其適用於治療對多巴胺D3受體調節有反應的疾病。在式I中，變數具有以下意義：m 為1或2，n 為1或2，A 係選自由以下組成之群：CH2、CH2CH2、CHFCH2及CF2CH2，R1 為所選擇之含氧環狀基團，諸如C3-C6環烷基，其攜有一個或兩個選自由OH、C1-C2烷氧基、氟化C1-C2烷氧基及羰基氧組成之群的含氧基團，R2 係選自由氫、OH及氟組成之群，R3a 係選自由氫及甲基組成之群，R3b 係選自由氫及甲基組成之群，R4 為分支C4-C6烷基或分支氟化C4-C6烷基，及R5 尤其為C1-C6烷基、氟化C1-C3烷基、C1-C2烷氧基-C1-C4烷基、氟化C1-C2烷氧基-C1-C4烷基、羥基-C1-C4烷基、氟化羥基-C1-C4烷基、氧雜環丁基、氟化氧雜環丁基、氧雜環戊基(oxolanyl)、氟化氧雜環戊基、C3-C5環烷基、氟化C3-C5環烷基等。
